T he physicist Richard Feynman once quipped that the key to solving or making significant progress on a scientific problem was to “find the open channel.” For the cell biological problem of nucleus-tocytoplasm transport, the literal open channels have long been known: the nuclear pore complexes (NPCs). However, in the metaphorical sense as well, recent work has significantly “opened” the NPC ch...

In Europe and North America, retinoblastoma has a reported incidence ranging from 1 in 14 000 to 1 in 36 000 live births'-5 and is the most common ocular malignancy affecting children and infants. Early diagnosis allows the application of a number of therapies directed at localised disease, including external beam and plaque radiotherapy, cryotherapy, and photocoagulation, although the principa...

Isatin (1H-indole-2,3-dione) is an endogenous compound that has been identified in humans and possesses a wide range of biological activities, such as anxiogenic and sedative activities. A variety of biological activities are associated with isatin, including central nervous system (CNS) activities (Raj, 2012). The single crystal X-ray diffraction study of the title compound has been made and i...

Equilibrium computation with continuous games is currently a challenging open task in artificial intelligence. In this paper, we design an iterative algorithm that finds an ǫ–approximate Markov perfect equilibrium with two–player zero–sum continuous stochastic games with switching controller. When the game is polynomial (i.e., utility and state transitions are polynomial functions), our algorit...

The Canadian Light Source (CLS) is a 2.9 GeV synchrotron that recently went into service. This paper presents some of the choices made in the design of this facility control system, and lessons learned from the CLS project. Some of the more novel technology choices in the design of the CLS include: (1) fully open source based operating system (RTEMS and Linux); (2) extensive use of fibreoptics ...

•A key phase transition intermediate (8H phase) was isolated and identified•Complete evolution of FAPbX3 by the 8H single crystal is provided•Effects doping anions cations on stabilization are revealed•Rational design for fabrication highly efficient stable PSCs suggested The stability formamidinium lead halide (FAPbX3) perovskites crucial to long-term perovskite solar cells, while a molecular-...

Studies on life cycles and epizootiology of North American frog bladder flukes indicate that adult frogs become infected predominantly by ingesting tadpoles or other frogs that serve as second intermediate hosts for gorgoderid metacercariae. Other studies have indicated that newly metamorphosed frogs are rarely infected with these parasites because they are gapelimited predators that cannot fee...

The aim of this paper is to contribute to the development of the Internationalization Process Model (IP model) through the use of a resource network perspective, based on industrial network theory. According to the IP model, firms internationalize through an incremental path characterized by small steps that are dependent on the firms and the networks resource combination. In this paper, it is ...