Herpes simplex virus infection is almost universal.this virus has two types:HSV1 and HSV2 infect about 500/000 persons annually in the united states,and its prevalence rate has increased during the past decade.Usually HSV1 spreads through kissing or casual contact and HSV2 through sexual intercourses.HSV1 is more frequently associated with oral infection and HSV2 can cause recurrent genital ulc...

The presence, frequency, and relationship of ocular and oral shedding of herpes simplex virus to previous herpes keratitis was investigated. This was to determine if a history of herpes keratitis predisposes to shedding of the herpes simplex virus into the tear film and/or mouth. Swabs were collected from the eyes and mouth of two groups of patients thrice weekly over a two- to four-month perio...

Although herpes zoster is not a reportable condition in the United States, its incidence has been inferred from a variety of studies to range from 3.2 to 4.2 per 1,000 patient-years. This incidence translates into an estimated 1 million cases of herpes zoster annually. Overall, an estimated 32% of persons in the United States will have herpes zoster during their lifetimes. In a recent populatio...

During neuronal latency of herpes simplex virus (HSV)-1, the latency-associated transcript (LAT) is the only viral gene readily detectable. LAT is required for the high-level reactivation phenotype in animal models. LAT's anti-apoptotic activity was recently demonstrated by our group and it was proposed that LAT's anti-apoptotic function is involved in enhancing the reactivation phenotype. Rece...

Several complications attributed with Herpes virus related infections and the emergence of drug resistant viruses prompt scientists to search for new drugs. Several terpenoids and coumarins have shown anti HSV effects while no sesquiterpene coumarin have been previously tested for HSV treatment. Three sesquiterpene coumarins [badrakemin acetate (1), kellerin (2) and samarcandin diasteromer (3) ...

OBJECTIVE To report the frequency of coexisting herpes viruses (herpes simplex virus 1 [HSV-1] or HSV-2, varicella zoster virus, Epstein-Barr virus [EBV], cytomegalovirus, or human herpes virus 6 [HHV-6]) and autoantibodies in patients with encephalitis (herpes or autoimmune) in clinical laboratory service. METHODS Three groups were evaluated for herpes viruses and antibodies: group 1-patient...

Background: Herpes Simplex Virus (HSV) infections are very common in Iran and worldwide and the risk for resistance to anti-herpetic drugs has increased recently. Alternative antiherpetic agents seem necessary to control and reduce the emergence of -resistant strains. Oriental medicine suggests some herbal options for the treatment of herpes lesions. Aim: This study reviews some of the common h...

herpetic keratitis which is resulted from herpes simplex virus type i, is considered the most common cause of corneal blindness that needs being diagnosed and treated in order to prevent irreversible eye effects. the best method to diagnose it is molecular method which has high sensitivity and exclusivity. the current study was done on 25 eye samples collected from patients referred to the feyz...

congenital varicella syndrome encompasses a broad spectrum of malformations present in children of mothers who developed chickenpox during the fi rst 20 weeks of gestation. we report a case of a monochorionic diamniotic twin pregnancy, with maternal exposure to chickenpox during the thirteenth week of gestation, which produced one symptomatic and one healthy child.