In order to combat the low regenerative capabilities of ligaments full ‘bone to bone’ replacements are required, which will integrate with bone while providing a smooth transition to the replacement soft tissue (tissues surrounding organs in the body, not being bone). This study investigated the use of 3D powder printing technology to form calcium phosphate brackets, previously used for forming...

We had previously demonstrated the feasibility of preparing a centimeter-sized bone tissue construct by following a modular approach. In the present study, the objectives were to evaluate osteogenesis and tissue formation of human amniotic mesenchymal stem cells-laden CultiSpher S microcarriers during in vitro perfusion culture and after subcutaneous implantation. Microtissues were prepared in ...

The long-term success of a total joint replacement can be undermined by loosening of the implant, generation of wear debris or a combination of both factors. In the present study the influence of the surface morphologies of the bone and cement mantle on loosening of cemented total joint replacements (THJRs) and development of wear debris were studied. Model cemented THJR specimens were prepared...

Initial stability is an essential prerequisite to achieve osseointegration of press-fit acetabular cups in total hip replacements. Most in vitro methods that assess cup stability do not reproduce physiological loading conditions and use simplified acetabular models with a spherical cavity. The aim of this study was to investigate the effect of bone density and acetabular geometry on cup stabili...