Only 10% to 20% of pancreatic tumors are resectable at the time of diagnosis. Patients with advanced disease have a median survival of 4.9 months. Palliation is often required for biliary or duodenal obstruction, or both, and for pain. Optimal palliation should guarantee the shortest possible hospital stay and as long a survival as possible with a good quality of life. In recent years, treatmen...

The role of radiotherapy in the palliation of painful symptomatic bone metastases is well established. Recently, it has been reported that single-fraction radiotherapy is as effective as multifraction radiotherapy ( 1 , 2 ) , which is the most widely used regimen. We read the interest the article by Hartsell et al. ( 3 ) , which compared the ability of a single 8-Gy fraction of radiation therap...

The vast majority of patients with metastatic castration-resistant prostate cancer (mCRPC) develop bone metastases. Bone metastases are a source of significant morbidity and affect quality of life in these patients. Several bone-targeting agents are approved for the treatment of bone metastases in prostate cancer, including bisphosphonates, denosumab, and radiopharmaceuticals. Radium-223 is a n...

BACKGROUND: Bone is the most frequent site of metastasis in patients with breast cancer. Bone metastasis, particularly osteolytic bone destruction, is usually associated with significant morbidity and deterioration of quality of life. Bisphosphonates are specific inhibitors of osteoclast activity used in the treatment of hypercalcemia of malignancy and osteolytic bone disease. METHODS: We revie...

simple bone cysts are usual, benign, fluid-filled, cystic lesions that often occur in the metaphysis of the long bones and are rarely detected in vertebrae. a case of a simple bone cyst in the body of the fifth lumbar vertebra in a 28-year-old woman with complaint of intermittent low back pain is described. according to the radiologic findings, the lesion was detected as a simple bone cyst, and...

Cryoablation is a safe and minimally invasive therapy option that provided rapid durable pain relief, as well an improved quality of life in participants with bone metastases.

OBJECTIVE To assess the outcome of yttrium-90 radiation synovectomy at 6 and 12 months in patients with knee osteoarthritis unresponsive to systematic or local medical treatment. METHODS Consecutive patients with osteoarthritic knee pain resistant to conventional therapy and submitted to intraarticular yttrium-90 treatment because of synovial inflammation, as demonstrated by early-phase bone ...