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The generation of neuronal cells from stem cells obtained from adult bone marrow is of significant clinical interest in order to design new cell therapy protocols for several neurological disorders. The recent identification in adult bone marrow of stem cells derived from the neural crests (NCSCs) might explain the neuronal phenotypic plasticity shown by bone marrow cells. However, little infor...

Background: Mesenchymal stem cells (MSCs) are beneficial for cell and gene therapy approaches. These highly potent in producing various cells, including adipocytes, osteoblasts, hematopoietic etc., particularly bone marrow-derived. High proliferation regenerative capacity important phenotypes of MSCs which contribute to the recovery process at damaged sites. Various techniques have been used, i...

Hematopoietic stem/progenitor cells (HSPCs) which give rise to different blood cell types are present within the bone marrow microenvironment, especially in flat bones such as skull, vertebrae, pelvis and chest. Interacting factors such as stromal derived factor-1/CXCR4, very late antigen-4/vascular cell adhesion molecule-1, Lymphocyte function-associated antigen-1/ intercellular adhesion molec...

hematopoietic stem/progenitor cells (hspcs) which give rise to different blood cell types are present within the bone marrow microenvironment, especially in flat bones such as skull, vertebrae, pelvis and chest. interacting factors such as stromal derived factor-1/cxcr4, very late antigen-4/vascular cell adhesion molecule-1, lymphocyte function-associated antigen-1/ intercellular adhesion molec...

Bone marrow hosts variety of tissues including hematopoietic lineage cells and mesenchymal stem cells (MSCs). The hematopoietic cells are the major source of the blood cells in the adult body which are regulated within the microenvironment of the stromal cells of the bone marrow [1]. MSCs are multipotent cells and can be differentiate into various cell lineage depend upon their environment and ...

objective(s) the use of co-culture cells as well as extra cellular matrix are among those strategies that have been employed to direct mesenchymal stem cell (msc) bone differentiation in culture. in this regard, there is no study considering the effects of matrigel on mesenchymal stem cell (msc) in vitro bone differentiation. this was the subject of the present study. materials and methods huma...

The last decade was dominated by dissemination of the notion that postnatal "mesenchymal stem cells," found primarily in bone marrow but also in other tissues, can generate multiple skeletal and nonskeletal tissues, and thus can be exploited to regenerate a broad range of tissues and organs. The concept of "mesenchymal stem cells" and its applicative implications represent a significant departu...

The aim of this study was to isolate mouse embryonic stem cells from late blastocyst stage embryos and to use them as a model system for the study of hematopoietic induction outside the embryo by coculturing of embryonic stem cells with bone marrow stromal cells. Blastocyst stage embryos from pregnant NMRI mice were obtained and cultured for 1-2 days in DMEM medium. The inner cell masses formed...

The use of biologic augmentation following microfracture for symptomatic cartilage defects the knee with osseous involvement shows encouraging results. Bone marrow aspirate concentrate provides growth factors to injury site, such as vascular endothelial factor, platelet-derived transforming factor-βa, and bone morphogenetic proteins in addition mesenchymal stem cells present concentrate. Cellul...