A multislice spin echo EPI sequence was used to obtain functional MR images of the entire rat brain with blood oxygenation level dependent (BOLD) and cerebral blood volume (CBV) contrast at 11.7 T. Maps of activation incidence were created by warping each image to the Paxinos rat brain atlas and marking the extent of the activated area. Incidence maps for BOLD and CBV were similar, but activati...

BACKGROUND Reference tissue-based quantification of brain PET data does not typically include correction for signal originating from blood vessels, which is known to result in biased outcome measures. The bias extent depends on the amount of radioactivity in the blood vessels. In this study, we seek to revisit the well-established Logan plot and derive alternative formulations that provide esti...

Cyclical fluctuations of cerebral blood flow velocity have been reported previously using Doppler ultrasound. The same phenomena was detected during investigations of changes in cerebral blood volume using near infrared spectroscopy. Rhythmic fluctuations of cerebral blood volume at a frequency of 3.5 cycles/minute is reported here.

The spatial distributions of functional activation of rat somatosensory cortex by forepaw stimulation were quantitatively compared using blood oxygen level dependent (BOLD) signal and signal weighted by cerebral blood volume (CBV). The BOLD contrast to noise (CNR) distribution showed a significant dorsal shift with respect to the CBV method at fields strengths of 2 T (0.69 +/- 0.09 mm) and 4.7 ...

A considerable body of data indicates that the plasma volume, as measured by dye dilution methods, is generally increased in congestive heart failure (1-4). However, recent investigations, utilizing p82 (5, 6) or Cr51 (7) tagged red cells, indicate that there is little or no increase in total blood volume, plasma volume, or red cell volume in most cases of heart failure. According to presently ...

Bronchoscopic treatment for emphysematous lung diseases has attracted clinical attention, and several different approaches are being investigated. We present a case of emphysematous bullae that was effectively treated with a newly developed bronchoscopic intervention, autologous blood injection. A 59-year-old man was referred to our institution with exertional dyspnoea. Chest CT showed emphysem...

We developed an experimental method which enabled continuous determination of the circulatory blood volume, when the blood volume was subjected to alterations. The blood volume was modified by a servo system to control transfer of the blood between an external reservoir and the cardiovascular system. Possible application of our method to the analysis of circulatory responses to blood volume cha...

IN ANALYZING the clinical and hemodynamic features of congestive heart failure due to myocardial disease or associated with mitral stenosis, many authors indicate or clearly imply that a significant augmentation in pulmonary blood volume plays a major role in the pathogenesis of pulmonary congestion and edema.'-6 These conclusions have depended largely upon indirect evidence such as clinical ev...