background: human t-lymphotropic virus (htlv), a retrovirus, is the causative agent of adult t-lymphocytic leukemia (atl) and tropical spastic paraparesia (tsp). htlv-1 is transmitted mainly through blood transfusion. sabzevar is an endemic region for htlv infection; hence it is essential to detect the prevalence of htlv1/2 infection in the blood donors of this city. materials and methods: in t...

diagnosis of hepatitis b is routinely based on of serological assay of hepatitis b surface antigen (hbsag). occult hepatitis b virus (hbv) infection is generally defined as the detection of hbv -dna in the serum or tissues of subjects who have negative test for hbsag. transmission of hbv infection has been documented from hbsag negative, anti-hbc positive blood and organ donors. the aim of this...

1Bristol Institute for Transfusion Sciences (BITS), National Blood Service, Bristol, United Kingdom; 2Department of Biochemistry, University of Bristol, Bristol, United Kingdom; 3Department of Chemistry, University of Aarhus, Aarhus, Denmark; 4School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom; 5New York Blood Center, New York City; and 6University of Californi...

Objective: Transfusion-related acute lung injury (TRALI) is a relatively uncommon complication in patients who undergo plasma-containing blood product transfusion. Despite the cross matching process, TRALI remains the most common cause of mortality associated with transfusion. We describe a case of TRALI in a 24year-old trauma patient who was successfully cared for on extracorporeal membrane ox...

introduction: the prevalence of somatic chromosomal abnormalities in infertile male individuals has been reported to vary in different literatures. the aim of this study was to investigate the frequency of chromosomal aberrations among infertile men referred to the cytogenetic laboratory of iran blood transfusion organization research centre (ibto). materials and methods: chromosomal analysis w...

Background: The incidence of glucose-6-phosphate dehydrogenase (G-6-PD) deficiency in Iran is estimated at 10-14.9%.  The donor blood in blood banks is not screened routinely for this enzyme deficiency and such blood may be used for neonatal exchange transfusion.Objective: To study the effect of G-6-PD deficient blood in neonatal exchange blood transfusion.Methods: In a prospective study, serum...

BACKGROUND The Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) is a 7-year multicenter transfusion safety research initiative launched in 2011 by the National Heart, Lung, and Blood Institute. STUDY DESIGN AND METHODS The domestic component involves four blood centers, 12 hospitals, a data coordinating center, and a central laboratory. The international component consists of ...

In the vein-to-vein flow of blood from donor to patient, the role of the transfusion medicine specialist has become increasingly centered at the bedside. Three clinically centered issues in blood safety and in blood conservation are presented in this chapter. In Section I, Dr. Patricia Hewitt presents the epidemiologic and clinical evidence regarding new variant Creutzfeldt-Jakob disease (nvCJD...