Referate – Abstracts – Analyses Physiology and Pathology of Blood Coagulation A Review of the Literature of 1950* (First Part) F. ROLLER, Zurich 1. General aspects. – 2. Prothrombin. – 3. Factor V (ac-globulin, labile factor). – 4. Thromboplastin. – 5. Platelets. – 6. Thrombín, antithrombin. – 7. Fibrinogen, fibrin. – 8. Heparin. – 9. Other anticoagulants. – 10. Thrombosis. -11. Hemophilia. 1. ...

Referate – Abstracts – Analyses Physiology and Pathology of Blood Coagulation A Review of the Literature of 1950* (First Part) F. ROLLER, Zurich 1. General aspects. – 2. Prothrombin. – 3. Factor V (ac-globulin, labile factor). – 4. Thromboplastin. – 5. Platelets. – 6. Thrombín, antithrombin. – 7. Fibrinogen, fibrin. – 8. Heparin. – 9. Other anticoagulants. – 10. Thrombosis. -11. Hemophilia. 1. ...

Description is given of changes in blood coagulability found in diseases of the rabbit, including malignant tumor, spontaneous infections, non-bacterial diseases and lesions, and hemorrhagic states specifically induced. The changes involved variously the time of onset of blood coagulation, clot formation rate and the rate and extent of clot retraction.

Although calcium is essential for the formation of thrombin, it can be recovered quantitatively from formed horse thrombin without affecting its coagulating activity. Citrate also has no significant effect. As stated in the text, this does not exclude the possibility that thrombin is actually a calcium compound present in minute concentration; but confirming the results of Hammarsten, it does s...

Bacterial endotoxins and antigen-antibody aggregates activate complement, accelerate blood coagulation, and are implicated in intravascular blood clotting (1-7). Tha t their effect on blood coagulation proceeds through the activation of the complement system has been suspected bu t has never been shown. We have found that these and other complement-activating materials initiate blood coagulatio...

Referate – Abstracts – Analyses Physiology and Pathology of Blood Coagulation A Review of the Literature of 1950* (First Part) F. ROLLER, Zurich 1. General aspects. – 2. Prothrombin. – 3. Factor V (ac-globulin, labile factor). – 4. Thromboplastin. – 5. Platelets. – 6. Thrombín, antithrombin. – 7. Fibrinogen, fibrin. – 8. Heparin. – 9. Other anticoagulants. – 10. Thrombosis. -11. Hemophilia. 1. ...

Accurate computer simulation of blood function can inform drug target selection, patient-specific dosing, clinical trial design, biomedical device design, as well as the scoring of patient-specific disease risk and severity. These large-scale simulations rely on hundreds of independently measured physical parameters and kinetic rate constants. However, the models can be validated against large-...

Crude or crystalline trypsin in proper concentration causes the blood or plasma of human beings, dogs, rabbits, guinea pigs, and horses to coagulate. It does not clot the fibrinogen directly, but reacts with prothrombin to form thrombin. Since trypsin thus has the same effect as the physiological system Ca plus platelets (or Ca plus tissue extracts), it is suggested as a tentative working hypot...

The 3-hydroxy-3-methylglutaryl (HMG)-coenzyme A (CoA) reductase inhibitors (statins) have been shown to exhibit several vascular protective effects, including antithrombotic properties, that are not related to changes in lipid profile. There is growing evidence that treatment with statins can lead to a significant downregulation of the blood coagulation cascade, most probably as a result of dec...