نتایج جستجو برای: blood coagulant assays

تعداد نتایج: 789631  

2015
Keri Csencsits-Smith Krill Grushin Svetla Stoilova-McPhie

BACKGROUND Hemophilia A is a congenital bleeding disorder caused by defective or deficient factor VIII (FVIII). The active form of FVIII is the co-factor for the serine protease factor IXa (FIXa) in the membrane-bound intrinsic tenase (FVIIIa-FIXa) complex. The assembly of the FVIIIa-FIXa complex on the activated platelet surface is critical for successful blood clotting. OBJECTIVES To charac...

Journal: :Thrombosis and haemostasis 2016
Colin Longstaff John Hogwood Elaine Gray Erzsebet Komorowicz Imre Varjú Zoltán Varga Krasimir Kolev

Neutrophil extracellular traps (NETs) composed primarily of DNA and histones are a link between infection, inflammation and coagulation. NETs promote coagulation and approaches to destabilise NETs have been explored to reduce thrombosis and treat sepsis. Heparinoids bind histones and we report quantitative studies in plasma and purified systems to better understand physiological consequences. U...

2015
Guo-Zhong Tao Bo Liu Rong Zhang Gigi Liu Fizan Abdullah Mary Cay Harris Mary L. Brandt Richard A. Ehrenkranz Corinna Bowers Camilia R. Martin R. Lawrence Moss Karl G. Sylvester

Necrotizing enterocolitis (NEC) is the most common gastrointestinal (GI) medical/surgical emergency of the newborn and a leading cause of preterm neonate morbidity and mortality. NEC is a challenge to diagnose since it often shares similar clinical features with neonatal sepsis. In the present study, plasma protein profiling was compared among NEC, sepsis and control cohorts using gel electroph...

Journal: :the iranian journal of pharmaceutical research 0
zeliha selamoglu nigde university campus cihan dusgun nigde university hasan akgul gaziantep university mehmet fuat gulhan aksarau university

it has been investigated the in vitro antioxidant properties of ethanol extracts of the contained-allantoin plants in this study. contained-allantoined plant samples plantago lanceolata, plantago major, robinia pseudoacacia, platanus orientalis and aesculus hippocastanum were tested at different concentrations. the antioxidant activities of plant samples were analysed by 1,1- diphenyl-2-picrylh...

Journal: :European Heart Journal 2021

Abstract Purpose To study SNP rs12204590 (T > A) with development of Acute Cerebrovascular Event in the patients cardiovascular pathology and risk factors its who are representatives east Siberian population. Material methods 260 participated a research (age [57.0; 51.0–62.0]) 272 control group [55.0; 51.0–62.0].). Among transferred Event, 157 men 103 women. The included 170 102 Inspecti...

Journal: :Emerging Infectious Diseases 2021

Abstract We describe results of testing blood donors in London, UK, for severe acute respiratory disease coronavirus 2 (SARS-CoV-2) IgG before and after lockdown measures. Anonymized samples from 17–69 years age were tested using 3 assays: Euroimmun IgG, Abbott an immunoglobulin receptor-binding domain assay developed by Public Health England. Seroprevalence increased 3.0% prelockdown (week 13,...

Journal: :Leprosy review 2000
H M Dockrell G F Black R E Weir P E Fine

Recent years have seen the introduction of a number of whole-blood assays, in which unseparated heparinized blood is stimulated with antigen either overnight or for as long as 6 days, and cytokine production is measured in the plasma or supernatant. These assays have potential for use in the field as immunodiagnostic assays, as they require only a small blood sample and basic laboratory facilit...

Journal: :Hormones 2008
Baris Akinci Serkan Yener Goksel Bengi Sena Yesil

It is widely known that metformin reduces the levels of circulating pro-coagulant factors and improve fibrinolytic activity in type 2 diabetes when used in therapeutic doses. Potential alterations of coagulation have not been reported in patients with metformin intoxication. We evaluated certain components of the coagulation system in a patient with metformin intoxication upon admission and aft...

Journal: :Critical Care 2006
Thomas Klitgaard Rene Tabanera y Palacios Kenneth D Boffard Philip TC Iau Brian Warren Sandro Rizoli Rolf Rossaint Yoram Kluger Bruno Riou

INTRODUCTION Recombinant activated factor VII (rFVIIa) has been used as adjunctive therapy in trauma patients with severe bleeding. However, its pharmacokinetics profile remains unknown. METHODS In two placebo-controlled studies in patients with blunt and penetrating trauma, the pharmacokinetics of rFVIIa given at an initial dose of 200 microg x kg-1 after transfusion of eight red blood cell ...

2017
Sahithi J Kuravi Clara M Yates Mark Foster Paul Harrison Jon Hazeldine Peter Hampson Chris Watson Antonio Belli Mark Midwinter Gerard B Nash

BACKGROUND Extracellular vesicles (EV) released into the circulation after traumatic injury may influence complications. We thus evaluated the numbers of EV in plasma over 28 days after trauma and evaluated their pro-coagulant and inflammatory effects. METHODS AND FINDINGS 37 patients suffering trauma with an injury severity score >15 were studied along with 24 healthy controls. Plasma sample...

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