background: the vascular response to recurrent tissue hypoxia and reperfusion following red blood cell sickling causes acute chest syndrome and chronic lung disease. the purpose of this study was to determine the pattern of chronic lung lesions and possible risk factors in sickle cell patients in lagos, nigeria.methods: from july 2012 to april 2013, pulmonary function test (pft) and chest-x-ray...

Abstract Background Endothelial progenitor cells (EPCs) are promising candidates for the cellular therapy of peripheral arterial and cardiovascular diseases. However, hitherto there is no specific marker(s) defining precisely EPCs. Herein, we proposing a new in silico approach finding novel EPC markers. Methods We assembled five groups chosen EPC-related genes/factors using PubMed literature Ge...

Blood is a liquid tissue in which dissolved with abundant chemical factors and millions of different cells The reduction of unwanted side effects, especially diseases that emerge through blood such as HIV and hepatitis, has a significant role for modern medicine of transfusion and transplantation. The issues and costs of human blood collection and storage, direct this procedure towards t...

PURPOSE Determinants of allogeneic blood use in cardiac surgery include preoperative factors such as female sex, age, body weight, hematocrit and red cell volume. We verified if these variables also predicted the need for allogeneic transfusions when autologous blood is predonated. METHODS Demographic and intraoperative variables, hemoglobin concentrations and transfusion requirements in pati...

The blood-brain barrier regulates the flow of ions, chemicals, and cells by acting as a conduit between blood cerebral tissue. Additionally, it shields brain against pathogen invasion immune cell infiltration. It is composed endothelial cells, pericytes, astrocytic end feet, perivascular macrophages, microglial which help in maintaining its integrity. There are various signaling pathways that a...

Background: Blood is permanently exposed to oxidation stress and therefore has a high antioxidants capacity. Many different factors increasing the demand for the antioxidant capacity can be observed in the stored blood of donors. Consequently, damage to erythrocytes by free radicals may occur. So it is useful to control the alternation of anti-oxidant enzymes in stored blood at different days o...

background: mesenchymal stromal cells (mscs) are employed in various different clinical settings in order to modulate immune response. human autologous and allogeneic supplements including platelet derivatives such as platelet lysate (pl), platelet-released factors (prf) and serum are assessed in clinical studies to replace fetal bovine serum (fbs). the immunosuppressive activity and multi-pote...

backgrounds: thyroid hormones play an important physiological role in human metabolism. erythrocyte abnormalities are frequently associated with thyroid disorder. however, they are rarely investigated and related to the subclinical and primary hypothyroidism in kashmiri patients. in this study an attempt was made to study hematological parameters in untreated and treated subclinical hypothyroid...