What's "too much" alcohol for a person will vary, based on a number of factors. Thinking about the immediate effects of alcohol consumption, the extent to which alcohol impacts health and behavior is directly related to blood alcohol concentration (BAC). A person's BAC varies, depending on the amount of alcohol consumed and how quickly it's metabolized. Metabolism may be affected by such factor...

BACKGROUND Variation in alcohol metabolism affects the duration of intoxication and alcohol use. While the majority of genetic association studies investigating variation in alcohol metabolism have focused on polymorphisms in alcohol or aldehyde dehydrogenases, we have now tested for association with genes in alternative metabolic pathways that catalyze the carbon skeleton of ethanol (EtOH) and...

OBJECTIVE The present study aimed to investigate if drinking one standard drink per hour could keep blood alcohol concentration below the legal limit of 0.05% in Thai men and women. MATERIAL AND METHOD After overnight fast, 15 healthy Thai men and 15 healthy Thai women received 12 g of ethanol by drinking beer, rum, or carbonate mixed rum and their blood alcohol concentrations were monitored ...

The goal of this report is to assess the relationship of varying levels of blood alcohol concentration (BAC) and hospital complications in patients admitted after motor vehicle crashes. Data for the study was collected by a retrospective review of the University of Wisconsin Hospital trauma registry between 1999 and 2007 using the National Trauma Registry of the American College of Surgeons (NT...

OBJECTIVE Nonexperimental survey and field research support the notion that alcohol use may be associated with deliberate self-harm (DSH) across the spectrum of lethality, from nonsuicidal self-injury (NSSI) through suicide. Nonexperimental studies, however, provide limited information about potential causal relationships between alcohol consumption and DSH. Two previous experiments showed that...

BACKGROUND Effects of cannabis, the most commonly encountered non-alcohol drug in driving under the influence cases, are heavily debated. We aim to determine how blood Δ(9)-tetrahydrocannabinol (THC) concentrations relate to driving impairment, with and without alcohol. METHODS Current occasional (≥1×/last 3 months, ≤3days/week) cannabis smokers drank placebo or low-dose alcohol, and inhaled ...

Background: Suicide is one of the leading external causes of death in many countries and its rates have increased globally over the last decades. The level of alcohol consumption and the suicide rates in the former Soviet republic Belarus range among the highest in the world. Aim: To estimate the aggregate level effect of alcohol on suicide rates in Belarus. Method: Trends in alcohol consumptio...

The aim of this study was to compare the pharmacokinetics of ethanol in saliva and blood according to gender and to evaluate the determination of ethanol in saliva for evidential sobriety testing. Twenty-four persons, 12 men and 12 women, took part in the experiments. The subjects received ethanol, as neat 40% v/v vodka, in the amount which should lead according to Widmark formula to the blood ...

BACKGROUND It is well recognized that both acute and chronic alcohol use are among the major behaviorally modifiable factors that are associated with suicidal behavior. There is suggestive evidence that binge drinking pattern, i.e. excessive consumption of strong spirits results in quicker and deeper level of intoxication, increasing the propensity for alcohol-related suicide. Although alcohol ...