Smooth muscle hamartoma (SMH), described by Stokes in 1923, is a proliferation of smooth muscle bundles. It can be single or multiple and may be congenital and acquired.1 The most frequent presentation is the localized congenital form, which is characterized by a plaque with a variable degree of hyperpigmentation, hypertrichosis, and induration. It is usually less than 10 cm in diameter and app...

Epidermal Nevus Associated with Cerebral and Ocular MR Imaging Abnormalities This letter focuses on Schimmelpenning syndrome (SS), a neurocutaneous disorder related to epidermal nevus syndromes and characterized by craniofacial nevus, neurologic anomalies, and ocular pathology. We discuss clinical and MR imaging features of a 10-year-old boy, pointing out the etiopathologic substratum of this c...

Monoamine oxidase (EC 1.4.3.4) exists in at least two forms (termed type A and type B) with different substrate and inhibitor specificities (Johnston, 1968; Knoll & Magyar, 1972). Amine neurotransmitters are among a wide range of substrates (Blaschko, 1974) and abnormalities of monoamine oxidase activity may therefore contribute to neurological disease. Most studies of such diseases have looked...

The monoamine oxiclases (MAO; EC 1.4.1.4), named by Zeller in 1938, are widely distributed in the animal kingdom (Blaschko, 1974; Hall and Uruena, 1983) and oxidize many biogenic and xenobiotic amines in the central nervous system and peripheral tissues. Thirty five years ago, MAO drew the attention of psychiatrists and pharmacologists when MAO inhibitors were found to be therapeutically effect...

I Lorenz RR, Vanhoutte PM: Inhibition of adrenergic ncurotransmission in isolated veins of the dog by potassium ions. J Physiol (Lond) 246: 479-500, 1975 2. Vanhoutte PM, Shepherd JT: Venous relaxation caused by acetylcholinc acting on the sympathetic nerves. Circ Res 32: 259-267, 1973 3. Vanhoutte PM, Loreiu RR, Tyce GM Inhibition of norepinephrine-'H release from sympathetic nerve endings in ...

The skin is like a canvas. Pigment distribution, skin appendages, skin ridges, etc. are arranged on the skin surface. The arrangement may be random but every now and then they form specific patterns. In some occasions, the specific arrangement is important for organism function or message display. In all occasions, these distinct arrays provide us with windows into the fundamental processes of ...

Manual image annotation is a tedious and timeconsuming task, while automated methods are error prone and limited in their results. Human computation, and especially games with a purpose, have shown potential to create high quality annotations by “hiding the complexity” of the actual annotation task and employing the “wisdom of the crowds”. In this demo paper we present two games with a single p...

The zosteriform distribution of cutaneous lesions is a common disease pattern in dermatology. It describes a unilateral girdle-like distribution restricted to the sensitive nerve territory of a dermatome. Three different pathogenic pathways can lead to a zosteriform pattern. The neural pathway uses the axons of a nerve ganglion for viral transport to a specific dermatome. The arche type is Herp...

Due to the existence of various views or representations in many real-world data, multi-view learning has drawn much attention recently. Multi-view spectral clustering methods based on similarity matrixes or graphs are pretty popular. Generally, these algorithms learn informative graphs by directly utilizing original data. However, in the real-world applications, original data often contain noi...

We report the case of a 16-month-old girl with hypomelanosis of Ito, a relatively rare phenotype associated with neurocutaneous manifestations. The characteristic hypopigmented streaks along the Blaschko lines were associated with hypertrichosis of the genitals and shins, as well as musculoskeletal and dental anomalies. An underlying endocrinologic disorder of the hypertrichosis could be exclud...