n engl j med 367;25 nejm.org december 20, 2012 2440 create an imbalance in the cytokine network, thereby driving or unmasking previously uncommon complications. The occurrence of pulmonary hypertension in one patient who received canakinumab and in two who received tocilizumab is notable, in light of a recent report of a significantly increased frequency of pulmonary hypertension in children wi...

Approved: Rakesh Gupta Thomas H. Miller The objectives of this study were to evaluate the performance of wood frame shear walls under monotonic, cyclic and earthquake loads by: (1) estimating the variability of shear wall performance, (2) comparing the performance of walls under each loading protocol, (3) evaluating the effects of anchorage on wall performance, and (4) evaluating the performanc...

Background Rheumatoid arthritis (RA) displays great heterogeneity between patients for susceptibility to developing erosions. Genetic variations within the HLA-DRB1 gene (the shared epitope (SE) and polymorphisms coding Valine at position 11) have been consistently associated with both radiographic outcome in RA.(1) However, associations of non-HLA markers are much less conclusive. Most studies...

Background: Belimumab (BEL), a monoclonal antibody that antagonizes B-lymphocyte stimulator, was first approved in 2011 for active, autoantibody-positive systemic lupus erythematosus (SLE). BEL has been studied over 10 years; and while safety data from individual trials have informative, large integrated analysis not yet conducted. Objectives: Perform pooled analyses to evaluate the of adult pa...

Micro electromechanical systems (MEMS) are finding uses in an increasing number of diverse applications. Currently the fabrication techniques used to produce such MEMS devices are primarily based on 2-D processing of thin films. The challenges faced by producing more complex structures (e.g. high aspect ratio, spans, and multi-material structures) require the development of new processing techn...

Corresponding author: Jae-Woo Yi, M.D., Ph.D., Department of Anesthesiology and Pain Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, 149, Sangil-dong, Gangdong-gu, Seoul 134-727, Korea. Tel: 82-2-440-6192, Fax: 82-2440-7808, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution No...

Gender and health has become an area of major research policy focus.1Hawkes S Allotey P Elhadj AS Clark J Horton R The Lancet Commission on Global Health.Lancet. 2020; 396: 521-522Summary Full Text PDF PubMed Scopus (7) Google Scholar Elissa Kennedy colleagues' meticulous study2Kennedy E Binder G Humphries-Waa K et al.Gender inequalities in wellbeing across the first two decades life: analysis ...

INTRODUCTION Pulmonary embolism (PE) is an entity with high mortality and morbidity, in which risk stratification for adverse events is essential. N-terminal brain natriuretic peptide (NT-proBNP), a right ventricular dysfunction marker, may be useful in assessing the short-term prognosis of patients with PE. AIMS To characterize a sample of patients hospitalized with PE according to NT-proBNP...

Aim/hypothesis: Leucine, isoleucine and valine are branched chain amino acids (BCAA). BCAAs areamong the 9 essential amino acids and are associated with beneficial health effects. However, previous studies have reported strong associations between increased BCAA levels, obesity and metabolic diseases such as type 2 diabetes. The objective of this study is to investigate the association between ...

To cite: Suchak T, Hussey J, Takhar M, et al. J Fam Plann Reprod Health Care Published Online First: [please include Day Month Year] doi:10.1136/jfprhc-2014101091 BACKGROUND UK figures estimate that in 1998 there were 3170 people over the age of 15 years assigned as male at birth who had presented with gender dysphoria. This figure is comparable to that found in the Netherlands where 2440 have ...