نتایج جستجو برای: bk virus bkv

تعداد نتایج: 402180  

Journal: :Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 2010
D Burgos C Jironda M Martín M González-Molina D Hernández

The infection by the BK Polyomavirus (BKV) is an emerging problem in kidney transplants that contributes to a chronic loss of kidney grafts, and in which immunosuppression plays a decisive role. Understanding its risk factors and strictly monitoring urine and serological markers of the infection could mitigate the undesirable effects of this disease. In this review, we investigate the clinical ...

Journal: :The Journal of general virology 2000
A Dolei V Pietropaolo E Gomes C Di Taranto M Ziccheddu M A Spanu C Lavorino M Manca A M Degener

BK and JC polyomaviruses (BKV and JCV) are widespread in humans and are thought to persist and reactivate under immune alterations. In addition to the kidney, lymphoid cells have been proposed as a site of latency. However, while this was shown to occur in immunocompromised patients, discordant data were published for healthy humans. To help to solve this issue, an extensive study (231 healthy ...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006
Dana E Rollison Eric A Engels Neal A Halsey Keerti V Shah Raphael P Viscidi Kathy J Helzlsouer

Viral infections have been associated with increased risk of non-Hodgkin's lymphoma (NHL). We conducted a nested case-control study to investigate the association between prediagnostic serum antibodies to the human polyomaviruses, JC (JCV) and BK (BKV), and subsequent risk of NHL. Two research serum banks were established in Washington County, Maryland, in 1974 and 1989, with the collection of ...

Journal: :American journal of clinical pathology 2010
Parmjeet S Randhawa Noush A Farasati Yuchen Huang Markus Y Mapara Ron Shapiro

Our objective was to determine whether quantitative polymerase chain reaction (PCR) can be used to measure the effect of tyrosine kinase (TK) inhibition on polyomavirus BK (BKV) replication. The BKV was grown in a cell culture system. The rate of viral replication in the presence or absence of the drug being tested was assessed by amplifying the viral genome using primers directed against the v...

Journal: :Antimicrobial agents and chemotherapy 2010
Christine Hanssen Rinaldo Rainer Gosert Eva Bernhoff Solrun Finstad Hans H Hirsch

Antiviral drugs for treating polyomavirus BK (BKV) replication in polyomavirus-associated nephropathy or hemorrhagic cystitis are of considerable clinical interest. Unlike cidofovir, the lipid conjugate 1-O-hexadecyloxypropyl cidofovir (CMX001) is orally available and has not caused detectable nephrotoxicity in rodent models or human studies to date. Primary human renal proximal tubular epithel...

2015
ZHANG-YANG WANG WEI-LONG HONG ZHE-HUI ZHU YUN-HAO CHEN WEN-LE YE GUANG-YU CHU JIA-LIN LI BI-CHENG CHEN PENG XIA

BK polyomavirus (BKV) is important pathogen for kidney transplant recipients, as it is frequently re-activated, leading to nephropathy. The aim of this study was to investigate the phylogenetic reconstruction and polymorphism of the VP2 gene in BKV isolated from Chinese kidney transplant recipients. Phylogenetic analysis was carried out in the VP2 region from 135 BKV-positive samples and 28 ref...

2016
Armine Darbinyan Eugene O. Major Susan Morgello Steven Holland Caroline Ryschkewitsch Maria Chiara Monaco Thomas P. Naidich Joshua Bederson Joanna Malaczynska Fei Ye Ronald Gordon Charlotte Cunningham-Rundles Mary Fowkes Nadejda M. Tsankova

Human BK polyomavirus (BKV) is reactivated under conditions of immunosuppression leading most commonly to nephropathy or cystitis; its tropism for the brain is rare and poorly understood. We present a unique case of BKV-associated encephalopathy in a man with hypohidrotic ectodermal dysplasia and immunodeficiency (HED-ID) due to IKK-gamma (NEMO) mutation, who developed progressive neurological ...

Journal: :The new microbiologica 2011
Caterina Patrizia Pollara Silvia Corbellini Stefania Chiappini Silvio Sandrini Dolores De Tomasi Carlo Bonfanti Nino Manca

Infection by polyomavirus BK (BKV) is an emerging problem in the clinical management of renal transplant patients because it is responsible for nephropathy and consequently can cause loss of the transplanted organ (BKV associated nephropathy, BKVAN). Aim of this study was to evaluate the use of blood viral load measurement as a screening tool for diagnosis of BKV infection and to identify a thr...

2013
H H Hirsch F Vincenti S Friman M Tuncer F Citterio A Wiecek E H Scheuermann M Klinger G Russ M D Pescovitz H Prestele

Polyomavirus BK (BKV)-associated nephropathy causes premature kidney transplant (KT) failure. BKV viruria and viremia are biomarkers of disease progression, but associated risk factors are controversial. A total of 682 KT patients receiving basiliximab, mycophenolic acid (MPA), corticosteroids were randomized 1:1 to cyclosporine (CsA) or tacrolimus (Tac). Risk factors were analyzed in 629 (92.2...

Hasan Jahanbakhsh-kotlar, Mahmoud-Reza Kalantari, Majid Khadem-Rezaiyan, Masoud Youssefi, Masoumeh Gharib, Saeed Amel-Jamehdar, Taban Javadzahed, Tahmine Bakhshi, Zahra Meshkat,

The BK virus a member of the Polyomaviruses family was first isolated from the urine of the kidney recipient. Infection with this virus and infection usually occurs in childhood (5-9 years) but most of the time (90%) of sera are positive and without symptoms. Polyomaviruses including the BK virus have also been suggested to be a contributing factor to some cancers in humans such as brain tumors...

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