OBJECTIVE To examine parents' preferences and willingness-to-pay (WTP) for HPV vaccines. METHODS A discrete choice experiment (DCE) was used. Parents with at least one daughter aged 9-13 years residing in Songkhla province were asked to choose one alternative from each DCE choice set describing HPV vaccines by four attributes, including cervical cancer risk reduction, genital warts risk reduc...

Bivalent promoters in embryonic stem cells (ESCs) carry methylation marks on two lysine residues, K4 and K27, in histone3 (H3). K4me2/3 is generally considered to promote transcription, and Polycomb Repressive Complex 2 (PRC2) places K27me3, which is erased at lineage-restricted genes when ESCs differentiate in culture. Molecular defects in various PRC2 null adult tissues lack a unifying explan...

Genomic imprinting is a developmental mechanism that mediates parent-of-origin-specific expression in a subset of genes. How the tissue specificity of imprinted gene expression is controlled remains poorly understood. As a model to address this question, we studied Grb10, a gene that displays brain-specific expression from the paternal chromosome. Here, we show in the mouse that the paternal pr...

Citation: Liao Y, Zhuang X, Huang X, Peng Y, Ma X, Huang Z-X, Liu F, Xu J, Wang Y, Chen W-M, Ye W-C and Shi L (2018) A Bivalent Securinine Compound SN3-L6 Induces Neuronal Differentiation via Translational Upregulation of Neurogenic Transcription Factors. Front. Pharmacol. 9:290. doi: 10.3389/fphar.2018.00290 A Bivalent Securinine Compound SN3-L6 Induces Neuronal Differentiation via Translation...

BACKGROUND The aim of this study was to assess the cost-effectiveness of human papillomavirus (HPV) vaccination in addition to the current cervical cancer screening programme in Germany using a dynamic transmission model. METHODS Based on a mathematical model simulating the transmission dynamics and the natural history of HPV infection and associated diseases (cervical intraepithelial neoplas...

Bivalent chromatin is characterized by occupation of both activating histone modifications and repressive modifications. While bivalent known to link with many biological processes, the mechanisms responsible for its multiple functions remain unclear. Here, we develop a mathematical model that involves antagonistic H3K4me3 H3K27me3 capture key features chromatin. Three necessary conditions emer...

İki değerli yapılar (bivalent elements) farklı dillerde biçim ve ses değeri açısından benzeyen dil göstergeleri olarak tanımlanabilir. Uzlaşının mutabakatın evrensel bir göstergesi haline dönüşen “okey” “yes” gibi tek sözcüklü sözceler ilk akla gelen iki yapılara örnek gösterilebilir. Bu yapıların ortak zeminde dilin konuşulmadığı bildirişim ortamlarında muhataplar arasındaki anlam müzakeresini...

Histone variant H2A.Z occupies the promoters of active and poised, bivalent genes in embryonic stem cells (ESCs) to regulate developmental programs, yet how it contributes to these contrasting states is poorly understood. Here, we investigate the function of H2A.Z.1 monoubiquitylation (H2A.Z.1ub) by mutation of the PRC1 target residues (H2A.Z.1(K3R3)). We show that H2A.Z.1(K3R3) is properly inc...

Cellular signaling is often propagated by multivalent interactions. Multivalency creates avidity, allowing stable biophysical recognition. Multivalency is an attractive strategy for achieving potent binding to protein targets, as the affinity of bivalent ligands is often greater than the sum of monovalent affinities. The bromodomain and extraterminal domain (BET) family of transcriptional coact...