Biological systems are often exposed to mechanical perturbations, which may modulate many biochemical processes. Ligand binding involves a wide range of structural changes in the receptor protein, from hinge movement entire domains minor sidechain rearrangements pocket residues. Hydrophobic ligand protein alters system’s vibrational free energy, allowing different conformational states alloster...

It is well known that flagellated bacteria, such as Escherichia coli , sense chemicals in their environment by a chemoreceptor and relay the signals via well-characterized signaling pathway to flagellar motor. widely accepted change rotation bias of motor without influencing speed. Here, we present results contrary show bacteria also capable modulating speed on merely sensing ligand. Step chang...

A novel ternary Schiff base ligand (HL) of ONO type and its copper (II) complex weresynthesised using 2-aminophenol and o-acetoacetotoluidide. They have been characterised by theusual analytical and spectral methods. The interaction of the complex with calf-thymus (CT)DNA has been investigated by UV-Vis, viscosity measurement, cyclic voltammetry anddifferential pulse voltammetry studies. The re...

Modafinil [2-[(diphenylmethyl)sulfinyl]acetamide] is used clinically in the treatment of narcolepsy and sleeping disorders. The synthesis of modafinil, begins with the reaction of benzhydrol and thioglycolic acid in trifluoroacetic acid to afford benzhydrylsulfinyl acetic acid. The reaction of acid with thionyl chloride in benzene followed by treatment with ammonium hydroxide gave acetamide...

In this study, the complexation of 2,3-dihydro-1H-phenothiazine-4(5aH)-one with 14 various cations were investigated by density functional theory. At the outset, the structures of the ligand, different cations and their derived complexes were optimized geometrically. Then, IR calculations were performed on them in order to acquire the formation enthalpy and Gibbs free energy values. The obtaine...

This new Schiff base ligand (L) were prepared from condensation reaction of 3-amino-4-(1-methoxy-1-oxo-3-phenylpropan-2-ylamino)-4-oxo butanoic acid(aspartame) with 4-(dimethyl amino benzaldehyde). A series complexes divalent, trivalent and tetravalent ions prepared. The the cobalt, nickel, copper, palladium, platinum gold have been characterized by several techniques such as C.H.N.O, FT-IR, mo...

One of the most important targets in Alzheimer disease is Beta site amyloid precursor protein cleaving enzyme-1 (BACE-1). It is a membrane associated protein and is one of the main enzymes responsible for amyloid β (Aβ) production. Up to now, a considerable number of peptidic and non-peptidic inhibitors of BACE-1 have been developed. Recently, small molecule BACE-1 inhibitors have attracted the...

A novel azo-Schiff base ligand (L) was prepared by reacting 2-hydroxy-5-(pyridine-4-yldiazenyl) benzaldehyde with 1,2-phenylenediamine. Moreover, Silver nanoparticles (Ag-NPs) and Cadmium sulfide nanoparticles (CdS-NPs) were prepared by employing azo-Schiff base ligand (L) as capping and reducing agent. The solid-state fluorescence spectroscopy was used to investigate the interaction between L ...

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of TNF family, is an interesting ligand which selectively induces apoptosis in tumor cells and, therefore, it has been developed for cancer therapy. This ligand has been produced by various hosts such as E.coli. However, protein expression in E.coli cytoplasm leads to problems such as incorrect folding, reduction in biolo...