This pilot study looks at the clinical application of bispectral index (BIS) monitoring within the palliative care situation. Using this instrument, the level of awareness in 12 patients was tracked from the onset of unconsciousness until death, and the levels were then related to the patients' clinical state and treatment. The results give a surprising insight into the nature of unconsciousnes...

This paper presents the automatic drug administration for the regulation of bispectral (BIS) index in the anesthesia process during the clinical surgery by controlling the concentration target of two drugs, namely, propofol and remifentanil. To realize the automatic drug administration, real clinical data are collected for 42 patients for the construction of patients’ models consisting of pharm...

BACKGROUND In a double-blind, randomized trial, we compared the haemodynamic effects of a bispectral index (BIS)-guided etomidate and propofol infusion for anaesthesia induction in patients undergoing major abdominal surgery. METHODS Forty-six patients were randomly assigned to two groups based on the induction of anaesthesia, performed with a BIS value of 60 titrated infusion of etomidate (E...

OBJECTIVE The performance of bispectral index (BIS) for the measurement of the sedative depth when dexmedetomidine is administered in propofol anaesthesia and sedation has not yet been established. This study evaluated the effects of adjunctive dexmedetomidine on the accuracy of BIS to predict loss of consciousness (LOC) and BIS values predicting LOC during propofol administration. METHODS In...

BACKGROUND Bispectral index (BIS) is a signal processing device that potentially is a pharmacodynamic measure of the effects of anaesthesia on the central nervous system. METHODS In this prospective blinded study, we investigated the pharmacodynamic relationship between BIS, haemodynamic changes during anaesthesia and endtidal nonsteady state concentrations of sevoflurane in 30 children, mean...

We report the case of a patient with a cerebral aneurysm, located in the left middle cerebral artery. During the clipping of this aneurysm, the bispectral index (BIS) increased for no apparent reason. This was then interpreted as intraoperative non-convulsive status epilepticus. This clinical condition may have negative impact in the prognosis of the patient, so it is very important to be able ...

A middle age man underwent immediate cardiopulmonary resuscitation (CPR) for ventricular fibrillation (VF) occurred in an ambulance. After arrival in a regional hospital, return of spontaneous circulation (ROSC) was achieved 82 minutes after the collapse. He was in coma even three hours after ROSC. So, he was transferred to our university hospital to receive therapeutic hypothermia (TH). An ini...

In this paper, we discuss the first application of recently developed L1-adaptive control methods for the closed-loop control of anesthesia delivery during surgery. Our initial objective, described herein, is to design controllers that are robust to inter-patient variability, such that patients follow a prespecified Bispectral Index (BIS) profile. The controllers are then evaluated on their abi...

This paper deals with the control of the induction phase of anesthesia. The objective during this first phase is to bring the patient from its awake state to a final state corresponding to some given depth of anesthesia, measured by the BIS (Bispectral index), within a minimum time. This optimal time control strategy is addressed by means of the maximum principle of Pontryagin. Furthermore, sin...