Mesoporous silica nanoparticles (MSNs) are promising solid supports for controlled anticancer drug delivery. Herein, we report biocompatible layer-by-layer (LbL) coated MSNs (LbL-MSNs) that are designed and crafted to release encapsulated anticancer drugs, e.g., doxorubicin hydrochloride (DOX), by changing the pH or by adding competitive agents. The LbL coating process comprises bis-aminated po...

the synthesis of some 9,10-disubstituted anthracene derivatives are described. 9,10-bis(2-bromoethyl) anthracene 4,9,10-bis (2-cyanoethyl) anthracene 5 and 9,10-bis (4-hydroxybutyl) anthracene 11 are synthesized for the first time.

SARS-CoV-2 has created an agonizing pandemic situation all over the world. The inhibition of main protease (Mpro) by blockage viral replication is considered important drug target to many researchers working discover specific drugs for COVID-19 treatment. Schiff bases being documented possess antimicrobial properties might be investigated as candidate against COVID-19. Bioactivities some symmet...

Objective(s): The main aim of current research was to develop a novel magnetically responsive hydrogel by radical polymerization of carboxymethyl cellulose (CMC) on acryl amide (Am) using N,N'-methylene bis acrylamide  (MBA)  as a crosslinking agent, potassium persulfate (KPS) as a free radical initiator, and  magnetic montmorillonite ( mMT)  nanoclay as nano-...

Attachment of drugs to high molecular weight polymers can significantly improve both tumor targeting and therapeutic efficacy due to the enhanced permeability and retention effect observed in tumor tissue. However, the commercial availability of well-defined water-soluble polymeric systems with narrow polydispersities that are biocompatible, nontoxic, and nonimmunogenic is rather limited. To ad...

In a prospective, comparative evaluation of therapy in advanced gastrointestinal carcinoma with 5-fluorouracil, mitomycin C, and 1,3-bis-(2-chlorethyl)-l-nitrosourea used alone, in double combination, and in triple combination, 215 adults with proved gastrointestinal adenocarcinoma were randomly assigned to one of seven possible treatment programs. Dosages and schedules were determined from the...

BACKGROUND This study was designed to assess the feasibility of dual closed-loop titration of propofol and remifentanil guided solely by the Bispectral Index (BIS) monitor in pediatric and adolescent patients during anesthesia. METHODS Children undergoing elective surgery in this single-blind randomized study were allocated into the closed-loop (auto) or manual (manual) group. Primary outcome...

The ability of various nitrosoureas to induce sister chromatid exchanges (SCEs) in 9L rat brain tumor cells was investigated. Treatment of cells for 1 hr with the alkylating and cross-linking agents 1,3-bis(2-chloroethyl)-1-nitrosourea or chlorozotocin produced concentration-dependent increases in SCEs; elevations above controls were detected at concentrations of 1 microM or more. Above 0.25 mM...

The devastating nature of the SARS-CoV-2 pandemic has fostered need for potent therapeutics to manage or curb disease’s severity. As a response, several studies on drug repurposing, vaccine design and optimizing natural phytochemicals are ongoing. This study aims at screening novel anti-COVID from rhizome Curcuma longa. A phytochemical library 50 nonubiquitous bioactive compounds longa was retr...