BACKGROUND A substantial number of people with bipolar disorder show a suboptimal response to treatment. AIMS To study the effectiveness of a collaborative care programme on symptoms and medication adherence in patients with bipolar disorder, compared with care as usual. METHOD A two-armed, cluster randomised clinical trial was carried out in 16 out-patient mental health clinics in The Neth...

AIMS This study investigated the hypothesis that direct epicardial bipolar mapping is able to predict the recovery of left ventricular (LV) dysfunction in ischaemic myocardium. METHODS AND RESULTS In 34 patients with CAD, a maximum of 102 bipolar epicardial electrograms per patient (n=3468 electrograms) were simultaneously recorded with a ventricular jacket array intraoperatively immediately ...

PURPOSE Although radiofrequency ablation (RFA) is a promising method for local treatment of liver malignancies, with conventional monopolar systems recurrence rates for large size tumours (≥3.5 cm) remain high. The objective of this study was to evaluate the safety, feasibility and local effectiveness of a novel bipolar plan-parallel expandable system for these larger tumours. METHODS AND MAT...

The purpose of this paper is to report choroidal atrophy in a patient with cancer-associated retinopathy who had autoantibodies against the transient receptor potential cation channel, subfamily M, member 1 (TRPM1). A 69-year-old man visited our clinic in July 2010 with complaints of blurred vision and night blindness in both eyes. The full-field electroretinograms were negative type, indicatin...

Tuberous sclerosis complex (TSC) is associated with significant psychiatric comorbidity mainly in the form of autistic disorders, hyperkinetic disorders, depression, and anxiety disorders. There are very few reports of bipolar disorder in TSC. The authors present the case of a patient with TSC having bipolar disorder manifesting as manic as well as depressive episodes. The diagnosis of TSC was ...

objective: several studies show co morbidity of anxiety disorders amongst patients with bipolar and unipolar disorders. it is associated with an intensification of symptoms, insufficient treatment response, non recovery, poor functional outcome and suicidality. the aim of this study was to show the frequency of anxiety disorders comorbidity and the relationship between comorbidity and suicide a...

introduction: substance abuse/dependency is one of the most important comorbidity in bipolar patients. therefore, recognizing the patterns of substance use is valuable in treatment and management of patients. this study was conducted to determine patterns of substance abuse among bipolar patients who were hospitalized in an educational hospital. methods : this was a descriptive-analytical study...

conclusions these findings support that the careful evaluation and prospective following of the psychopathology of children of parents with bipolar disorder are critical for early identification and treatment. results there were statistically significant differences between children of parents with and those without bipolar disorder regarding attention deficit hyperactivity disorder, opposition...

objective: bipolar i disorder is a common disorder with a complex etiology. a genetic approach is gaining increasing importance in this disorder. the dysbindin gene, located at 6p22.3 is considered a susceptibility gene for schizophrenia. certain genotypes of dysbindin are thought to be associated with other psychoses such as bipolar disorders. this study intends to assess the association in pr...

INTRODUCTION Cognitive impairment in the euthymic phase is a well-established finding in bipolar disorder. However, its brain structural and/or functional correlates are uncertain. METHODS Thirty-three euthymic bipolar patients with preserved memory and executive function and 28 euthymic bipolar patients with significant memory and/or executive impairment, as defined using two test batteries,...