OBJECTIVE Recent research has emphasized important gender differences in the epidemiology, course, comorbidity and treatment of bipolar disorder. This article aims to provide an overview of these important findings in order to assist the clinician in treating women with bipolar disorder. Complex issues regarding the treatment of bipolar disorder during pregnancy and the post-partum period are d...

OBJECTIVES Functional neuroimaging methods have proliferated in recent years, such that functional magnetic resonance imaging, in particular, is now widely used to study bipolar disorder. However, discrepant findings are common. A workgroup was organized by the Department of Psychiatry, University of Cincinnati (Cincinnati, OH, USA) to develop a consensus functional neuroanatomic model of bipol...

CONTEXT Individuals with early onset of bipolar disorder are at high risk for suicide. Yet, no study to date has examined factors associated with prospective risk for suicide attempts among youth with bipolar disorder. OBJECTIVE To examine past, intake, and follow-up predictors of prospectively observed suicide attempts among youth with bipolar disorder. DESIGN We interviewed subjects, on a...

Progress in the treatment of bipolar disorder Bipolar affective disorder has long been recognized as being one of the most significant causes of increased mortality and morbidity due to mental ill health. Bipolar disorder is an evolution of the older concept of manic-depressive illness, which itself was differentiated from dementia praecox/schizophrenia by Kraepelin over 100 years ago. Bipolar ...

OBJECTIVE To examine white matter microstructure, as assessed via diffusion tensor imaging (DTI), in adolescents with bipolar I disorder compared with control volunteers. METHOD Twenty-six (12 male and 14 female subjects) adolescents (mean age, 16.0 years) with bipolar I disorder and 26 (14 male and 12 female subjects) control volunteers (mean age, 15.3 years) completed structural and DTI exa...

OBJECTIVES Bipolar disorder is accompanied by cognitive impairments, which persists during euthymic phases. The purpose of the present study was to identify those neuropsychological tests that most reliably tell euthymic bipolar patients and controls apart, and to clarify the extent to which these cognitive impairments are clinically significant as judged from neuropsychological norms. METHOD...

background: anxiety disorders and substance abuse are commonest comorbidities among bipolar i disorder (bid) patients. this study investigated the prevalence of anxiety disorders among bid patients based on their dependency on opioid. methods: in this cross sectional study the bid patients in iranian hospital of psychiatry were divided into two 89-patient groups; one group was considered as opi...

background drug addiction, obsessive compulsive disorders (ocd), and other anxiety disorders are the disorders most commonly found in patients with bipolar disorder. objectives the purpose of this study was to identify the factors affecting the risk of drug addiction, obsessive compulsive disorders, and other anxiety disorders in patients with bipolar disorder. patients and methods in this retr...

OBJECTIVE There has been little investigation of early trauma in bipolar disorder despite evidence that stress impacts on the course of this illness. We aimed to compare the rates of childhood trauma in adults with bipolar disorder to a healthy control group, and to investigate the impact of childhood trauma on the clinical course of bipolar disorder. METHODS Retrospective assessment of child...