Controlled binding and assembly of peptides onto inorganic substrates is at the core of bionanotechnology and biological-materials engineering. Peptides offer several unique advantages for developing future inorganic materials and systems. First, engineered polypeptides can molecularly recognize inorganic surfaces that are distinguishable by shape, crystallography, mineralogy, and chemistry. Se...

Research supported by this grant entitled “Passive Sensor Materials Based on Liquid Crystals” revolved around an investigation of liquid crystalline materials for use in passive sensors for chemical agents, including sulfur and phosphorus-containing compounds. The research was founded on the discovery in the Abbott research group at University of Wisconsin that competitive molecular interaction...

| A rapidly expanding area of research in materials science involves the development of routes to complex 3D structures with feature sizes in the mesoscopic range (that is, between tens of nanometres and hundreds of micrometres). A goal is to establish methods for controlling the properties of materials systems and the function of devices constructed with them, not only through chemistry and mo...

1 Proteostasis Jeffery W. Kelly, MD Departments of Chemistry and Molecular and Experimental Medicine, and The Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, CA The chemical information within the polypeptide chain, coand post-translational modifications of the amino acids comprising the protein, such as N-linked glycosylation, and the interactions of the polypep...

We use several techniques to characterize the monolayer formed in air by the electron transfer protein, azurin, self-assembled on a gold substrate in a stable way. Tapping Mode Atomic Force Microscopy and Scanning Tunnelling Microscopy scans reveal the presence of individual molecules highly packed and stably bound to gold. The height of the single molecules, as determined by Atomic Force Micro...