a r t i c l e i n f o Keywords: Biodegradable polymer PHBHHx Kaolin Core–shell nanoparticle Nanocomposite A novel biodegradable nanocomposite was fabricated based on poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) and silane-modified kaolinite/silica core–shell nanoparticles (SMKS), via solution-casting method using chloroform as solvent. Unmodified (ORK) and glycidoxypropyltrimethoxysi...

Paclitaxel (Taxol) is one of the best antineoplastic drugs found from nature in the past decades. Like many other anticancer drugs, there are difficulties in its clinical administration due to its poor solubility. Therefore an adjuvant called Cremophor EL has to be employed, but this has been found to cause serious side-effects. However, nanoparticles of biodegradable polymers can provide an id...

INTRODUCTION Paclitaxel is a natural antineoplastic drug. It has been approved by the Food and Drug Administration (FDA) for the treatment of various cancers, especially ovarian and breast cancers with the best effect over other anticancer agents. Due to its high hydrophobicity however, an excipient such as Cremophor EL has to be used, which causes additional serious side effects. This study wa...

Poly(oxyethylene aminophosphonate)s synthesized on the basis of biodegradable poly(phosphorester)s and Schiff bases were tested in vitro for antitumor activity against a panel of six human epithelial cancer cell lines, for cytotoxicity to mouse fibroblast cells and in vivo for clastogenicity and antiproliferative effects. The polymers showed lower cytotoxicity, both in vivo and in vitro and low...

Natural and synthetic polymers are widely used as drug delivery tools in pharmaceutical and nanomedicine biotechnology [1-5]. Among synthetic polymers, dendrimers, a family of cationic polymers, are promising nonviral vectors for gene and drug delivery because of a well-defined molecular shape, controlled chemical structure, high water solubility, large number of chemically versatile surface gr...

EDITORIAL article Front. Mater., 16 June 2023Sec. Biomaterials and Bio-Inspired Materials Volume 10 - 2023 | https://doi.org/10.3389/fmats.2023.1231445