Carotenoids are non-polar compounds found in fruits and vegetables. The consumption of these has been associated with many beneficial effects on human health, especially the prevention chronic diseases that currently considered as problems public health. These have mainly attributed to antioxidant properties carotenoids, although other mechanisms involved, including influence carotenoids expres...

Cyclic N-substituted glycines oligomers, also known as cyclic peptoids, constitute a promising class of novel peptidomimetics, capable simulating bioactive effectors with enhanced proteolytical stability and cell permeability crucial bonuses. The macrocyclic constraint, essential for the induction stable secondary structures, determines biomimetic potential such molecules, which act antimicrobi...

Predicting bioactivity of compounds to drug target proteins using machine learning met hods is one of the most intensively studied area in drug discovery and development. Although many previous machine learning studies have succeeded in predicting novel ligand -protein interactions with high performance, all of the previous studies to date have been heavily dependent on the simple use of raw bi...

Litsea salicifolia is one of the many plants used as phytopesticide, traditionally by various tribes of Assam. Of the five extracts of L. salicifolia tested for the bioactivity against Aedes aegypti and Culex quinquefasciatus, the aqueous extract was more effective compared to other extracts exhibiting bioactivity at 72 ppm against A. aegypti. The hexane extract (2000 ppm) exhibited 70% repelle...

A cell survival assay of the four arabinosyl uridine analogs with functionalities of 5-fluoro, 5-fluorovinyl, 5-iodo, and 5-iodovinyl as potential positron-emitter tagged probe for monitoring cancer gene therapy were performed. Cytotoxicities of 5-fluoro-, 5-iodo-, 5-fluorovinyl, and 5-iodovinyl arabinosyl uridines against SR-39 thymidine kinase transfected murine prostate cancer cells have bee...

In the present study, the chemical investigation of the bioactive fractions of the rhizomes of Zingiber officinale has resulted in the identification of twenty-nine compounds including one new compound, O-methyldehydrogingerol. Some of the isolates were subjected into the evaluation of their antiplatelet aggregation and vasorelaxing bioactivities. Among the tested compounds, [6]-gingerol and [6...