Peptide natural products show broad biological properties and are commonly produced by orthogonal ribosomal and nonribosomal pathways in prokaryotes and eukaryotes. To harvest this large and diverse resource of bioactive molecules, we introduce here natural product peptidogenomics (NPP), a new MS-guided genome-mining method that connects the chemotypes of peptide natural products to their biosy...

Bioactive peptides are released during the production of fermented dairy, vegetables, fruits, legumes, fish, and meat products. The proteolytic specificity lactic acid bacteria, Bacillus spp., yeasts, mold, apart from their ability to synthesize bioactive peptides, plays an important role in generation specific traditional foods. Controlled fermentation using defined starter strains has been ex...

Previous work has revealed robust dorsal root ganglia neurite growth in hydrogels of chondroitin sulfate. In the current work, it was determined whether addition of a synthetic bioactive peptide could augment neurite growth in these matrices via enhanced binding and sequestering of growth factors. Fluorescence recovery after photobleaching studies revealed that addition of peptide slowed nerve ...

By-products and surpluses from food industries could generate peptides with great interest for food formulation. Hence, the separation and concentration of bioactive peptides from natural sources becomes increasingly attractive to the food industry [1]. Recently, a snow crab byproducts hydrolysate showed antibacterial activity [2]. This activity was due to an antibacterial peptide of about 800 ...

XTENs are unstructured, nonrepetitive protein polymers designed to prolong the in vivo half-life of pharmaceuticals by introducing a bulking effect similar to that of poly(ethylene glycol). While XTEN can be expressed as a recombinant fusion protein with bioactive proteins and peptides, therapeutic molecules of interest can also be chemically conjugated to XTEN. Such an approach permits precise...

Self-assembled peptide nanostructures have shown great potential as promising biomaterials. Peptides have the advantage of being intrinsically biocompatible materials. Peptides, as self-assembling building blocks, have mostly been designed to have head/tail molecular configuration. Since there is a great deal of interest in the precise control of a self-assembly process, novel building blocks s...

Abstract Peptide self-assembles with bionic properties have been widely utilized for bioactive drugs and biomedical materials. Collagen mimetic peptide (CMP) gains more attention due to its unique advantages in biosecurity function. Unfortunately, the self-assembly mechanism of CMP, particularly effect intermolecular forces on behavior morphology, is still unrecognized. Herein, hydrophilic glyc...

One emerging principle is that neuromodulators, such as neuropeptides, regulate multiple behaviors, particularly motivated behaviors, e.g., feeding and locomotion. However, how neuromodulators act on multiple neural networks to exert their actions remains poorly understood. These actions depend on the chemical form of the peptide, e.g., an alternation of L- to D-form of an amino acid can endow ...

Many neurodegenerative disorders (NDDs) are characterized by aggregation of aberrant proteins and extensive oxidative stress in brain cells. As a treatment option for NDDs, RNA interference (RNAi) is a promising approach to suppress the activation of abnormal genes and negative regulators of antioxidant genes. Efficient neuro-targeted siRNA delivery requires a delicate optimization of nucleic a...

objective: osseous defects around dental implants are often seen when implants are placed in areas with inadequate alveolar bone, or around failing implants. bone regeneration in these areas using bone grafts or its substitutes may improve dental implants prognosis. the aim of this study was to prepare and characterize the bioactive glass nanopowder and development of its coating for treatment ...