The assessment of new therapeutic strategies to cure surfactant-associated lung disorders would greatly benefit from assay systems allowing routine evaluations of surfactant functions. We present a method to measure surfactant adsorption kinetics into interfacial air-liquid interfaces based on fluorescence microplate readers. The principle of measurement is simple, robust, and reproducible: Wel...

BACKGROUND Preclinical studies suggest that exogenous surfactant may be of value in the treatment of the acute respiratory distress syndrome (ARDS), and two phase 2 clinical trials have shown a trend toward benefit. We conducted two phase 3 studies of a protein-containing surfactant in adults with ARDS. METHODS In two multicenter, randomized, double-blind trials involving 448 patients with AR...

PURPOSE To compare the efficacy of the new drug calfactant with the commonly used drugs surfactant-TA and poractant alfa. MATERIALS AND METHODS A total of 332 preterm infants at 24-31 weeks' gestation with respiratory distress syndrome (RDS) were enrolled and allocated to three groups according to the surfactant instilled; Group 1 (n=146, surfactant-TA), Group 2 (n=96, calfactant), and Group ...

Background: Hyaline cartilage defects exhibit a major challenge in the field of orthopedic surgery owing to its limited repair capacity. On the other hand, mesenchymal stem cells (MSCs) are regarded as potent cells with a property of cartilage regeneration. We aimed to optimize marrow-derived MSC chondrogenic culture using a small bioactive molecule referred to as BIO. Methods: MSCs from the ma...

SnCl4/nano-sawdust was prepared as a carbohydrate-based catalyst containing of tin bearing cellulose units. The catalyst was characterized by X-ray diffraction (XRD), fourier transform infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FESEM) and energy dispersive X-ray spectroscopy (EDS). The catalyst was applied successfully as a readily available, inexpensive, biodeg...

The key feature of respiratory distress syndrome (RDS) is the insufficient production of surfactant in the lungs of preterm infants. As a result, researchers have looked into the possibility of surfactant replacement therapy as a means of preventing and treating RDS. We sought to identify the role of surfactant in the prevention and management of RDS, comparing the various types, doses, and mod...

Host defense roles for the lung collectins, surfactant protein A (SP-A) and surfactant protein D (SP-D), were first suspected in the 1980s when molecular characterization revealed their sequence homology to the acute phase reactant of serum, mannose-binding lectin. Surfactant protein A and SP-D have since been shown to play diverse and important roles in innate immunity and pulmonary homeostasi...

core flooding experiments were conducted with the objective of evaluating near miscible surfactant alternating co2 injection and the effect of surfactant concentrations on gas-oil and water displacements in porous media. the core samples were provided from a low permeability mixed wet oil reservoir at 156 °f and 1900 psia. in addition, very few studies of surfactant adsorption on carbonate mine...

in this research, effect of bicomponent mixed surfactant was studied on drop interface coalescence phenomenon in ambient temperature. first basic chemical system was water and toluene and 0.01 gr of sodium dodecyle sulfate (sds) and the second basic system was water and toluene and 0.01 gr of cethyl trimethy amonium bromide (ctab). various weight fractions of second surfactant including 2-hepta...