Evolutionary Analysis of Mammalian ACE2 and the Key Residues Involved in Binding to Spike Protein Revealed Potential SARS-CoV-2 Hosts

The protein corona is an obstacle to exploiting exotic properties of nanomaterials in clinical and biotechnological settings. atomic-scale dynamic formation the at bio-nano interface impenetrable using conventional experimental techniques. Here, molecular dynamics simulations are used study effect graphene-oxide (GO) functionalization on apolipoprotein-cIII (apo-c3) adsorption. An analysis pipe...

Coronaviruses such as SARS-CoV-2, which is responsible for COVID-19, depend on virus spike protein binding to host cell receptors cause infection. The SARS-CoV-2 binds primarily ACE2 target cells and then processed by membrane proteases, including TMPRSS2, leading viral internalisation or fusion with the plasma membrane. It has been suggested, however, that other than may be involved in binding...

background: the development and progression of human tumors is accompanied by various cellular biochemical and genetic alterations. these events include tumor cells interaction with extracellular matrix molecules including hyaluronan and hyaluronan binding protein (ha-habp). hyaluronan is a large polysaccharide associated with pericellular matrix of proliferating, migrating cells, regulation of...

Background: TGF-β isoforms play crucial roles in diverse cellular processes. Therefore, targeting and inhibiting TGF-β signaling pathway provides a potential therapeutic opportunity. TGF-β isoforms bind and bring the receptors (TβRII and TβRI) together to form a signaling complex in an ordered manner. Objectives: Herein, an antagonistic variant of TGF-β (AnTβ)...

Abstract In December 2019, a novel respiratory tract infection, from severe acute syndrome coronavirus 2 (SARS-CoV-2), was detected in China that rapidly spread around the world. This virus possesses spike (S) glycoproteins on surface of mature virions, like other members coronaviridae. The S glycoprotein is crucial viral protein for binding, fusion, and entry into target cells. Binding recepto...