Protein-protein interactions, particularly weak and transient ones, are often mediated by peptide recognition domains, such as Src Homology 2 and 3 (SH2 and SH3) domains, which bind to specific sequence and structural motifs. It is important but challenging to determine the binding specificity of these domains accurately and to predict their physiological interacting partners. In this study, th...

Cytochrome P450 2D6 (CYP2D6) is used to develop an approach for predicting affinity and relevant binding conformation(s) for highly flexible binding sites. The approach combines the use of docking scores and compound properties as attributes in building a neural network (NN) model. It begins by identifying segments of CYP2D6 that are important for binding specificity, based on structural variab...

In affinity proteomics, specific protein-binding molecules (a.k.a. binders), principally antibodies, are applied as reagents in proteome analysis. In recent years, advances in binder technologies have created the potential for an unprecedented view on protein expression and distribution patterns in plasma, cells and tissues and increasingly on protein function. Particular strengths of affinity ...

BACKGROUND High levels of serum phosphorus both at baseline and during follow-up are associated with increased mortality in dialysis patients, and administration of phosphate binders was independently associated with improved survival among hemodialysis population. Calcium-based phosphate binders are the most commonly used phosphate binders in developing countries for their relatively low costs...

Engineered combinatorial libraries derived from small protein scaffolds represent a powerful tool for generating novel binders with high affinity, required specificity and designed inhibitory function. This work was aimed to generate a collection of recombinant binders of human interleukin-23 receptor (IL-23R), which is a key element of proinflammatory IL-23-mediated signaling. A library of var...

Endothelial dysfunction underlies multiple cardiovascular consequences of chronic kidney disease (CKD) and antecedent diabetes or hypertension. Endothelial insults in CKD or end-stage renal disease (ESRD) patients include uremic toxins, serum uric acid, hyperphosphatemia, reactive oxygen species, and advanced glycation endproducts (AGEs). Sevelamer carbonate, a calcium-free intestinally nonabso...

Stabilisation/solidification (S/S) technology, which basically involves chemical fixation and immobilisation of contaminants, mainly metals, in the matrix of cementitious binders, is widely used for treatment of contaminated soils. This paper presents a critical review of the performance of commonly used blended binder systems in S/S technology. The binders considered are Portland cement, and c...

Paints are used to protect and prolong the life of natural synthetic materials as it acts a barrier against environmental conditions. contain extenders, solvents, pigments, binders, some additives. The objective is improve physical properties current matt paint formulation. contents acrylic white emulsion known be 25%Pigments, 12% Extender 5% Additives, 44% Solvents, 14% Binders. [2]. Binders m...

Polymer Binders In article number 2103663, Wen Luo and co-workers develop powder catalysts coated with a polymer binder for enhanced electrochemical CO2 reduction to multi-carbon products, inspired by water-repulsive surfaces in nature. The use of hydrophobic binders increases the local concentration gas reactants reaction intermediates, enhancing reaction.

BACKGROUND AND AIMS The efficacy of phosphate binders is difficult to be estimated clinically. This study analyzes the changes in serum phosphate and urinary phosphate excretion after the prescription of phosphate binders (PB) in patients with chronic kidney disease stage 4-5 pre-dialysis, and the usefulness of the ratio between total urinary phosphate and protein catabolic rate (Pu/PCR) for es...