A case of transcobalamin II deficiency with several unique features is described. The clinical presentation was typical. except for a slightly delayed age at presentation and the occurrence of apparent neurologic dysfunction from the beginning. The unusual biochemical feature was a low serum cobalamin level (97 pg/mI). Several cobalaminbinding protein abnormalities coexisted and antedated cobal...

We wish to make the following changes to the published article [1], agreed upon by all authors. Claudia R. Binder has withdrawn her co-authorship. The corrected author list should therefore read: Camilo Lesmes-Fabian. Camilo Lesmes-Fabian thanks Claudia R. Binder for her comments and inputs to earlier drafts of this publication. The author would like to apologize for any inconvenience caused to...

Hybrid Logics are usually presented as an extension of modal logics where we can explicitly refer to the elements in the model. In this paper we will start by introducing hybrid logics from that perspective, and we will complete this presentation with a historical overview. But we will later have a closer look to the ↓ binder, and propose an alternative way to think about it. We will explain th...

The use of recycled materials in pavement construction has seen, over the years, a significant increase closely associated with substantial economic and environmental benefits. During the past decades, many transportation agencies have evaluated the effect of adding Reclaimed Asphalt Pavement (RAP), and, more recently, Recycled Asphalt Shingles (RAS) on the performance of asphalt pavement, whil...

Sucroferric oxyhydroxide (VELPHORO) is a polynuclear iron-based phosphate binder recently approved for the treatment of hyperphosphataemia in patients with chronic kidney disease (CKD). As a number of the available phosphate binders do not provide the optimal combination of good efficacy, adequate tolerability and low pill burden, sucroferric oxyhydroxide constitutes a promising alternative. Am...

The aim of this study was to design and optimize a new tablet formulation for treatment of copper deficiency in human organism by using an experimental design. The new no-veneered tablets, prepared by a wet granulation technique, are containg active substance, a copper(II) complex with polysaccharide pullulan. The binder concentration, the disintegrant concentration and the resistance to crushi...