PURPOSE To compare the capabilities of apparent diffusion coefficient (ADC) and normalized ADC using the pancreatic parenchyma as reference organ in the characterization of focal pancreatic lesions. PATIENTS AND METHODS Thirty-six patients with focal pancreatic lesions (malignant, n=18; benign tumors, n=10; focal pancreatitis, n=8) underwent diffusion-weighted MR imaging (DWI) at 1.5-Tesla us...

Pancreatic hamartoma is an extremely rare, non-neoplastic, mass-forming lesion that may be mistaken for malignancy, and the pre-operative diagnosis is particularly challenging. The published literature contains only 23 cases of pancreatic hamartoma. The majority of the cases reported patients with a single benign tumor-like disease that received a pancreatectomy. Immunohistochemical findings co...

Fifty years ago, the group of Tony Mathias and Bob Rabin at University College London deduced the first mechanism for catalysis by an enzyme, ribonuclease [Findlay, D., Herries, D. G., Mathias, A. P., Rabin, B. R., and Ross, C. A. (1961) Nature 190, 781-784]. Here, we celebrate this historic accomplishment by surveying knowledge of enzymology and protein science at that time, facts that led to ...

Several experimental studies of pulmonary emphysema using animal models have been described in the literature. However, only a few of these studies have focused on the assessment of ergometric function as a non-invasive technique to validate the methodology used for induction of experimental emphysema. Additionally, functional assessments of emphysema are rarely correlated with morphological pu...

Pancreatic cancer is a disease with essentially no effective treatment. To increase the potential for discovering effective treatment, we have devel oped a new treatment model whereby a human pancreatic cancer line, PANC-4, was orthotopically transplanted to the pancreas of nude mice as historically intact tumor tissue. The tumor grew with subsequent inva sive local tumor growth and liver and p...

Obesity has been growing in Brazil and the world. It is reaching epidemic proportions, bariatric surgery most effective treatment for patients with this disease. Among procedures described literature, ileal surgeries such as biliopancreatic diversion duodenal switch (BPD-DS) single-anastomosis duodeno-ileal bypass sleeve gastrectomy (SADI-S) present better long-term results terms of weight loss...

Bariatric surgery is a type of weight loss that commonly used to treat obesity. However, this can also affect the body’s calcium and PTH metabolism, leading development secondary hyperparathyroidism (SHPT). Several factors contribute SHPT after bariatric surgery. Malabsorption due reduced intestinal surface area, decreased intake calcium-rich foods, altered vitamin D metabolism play significant...

The majority of patients with gastrointestinal cancers are over the age of 65. This age group comprises the minority of the patients enrolled in clinical trials, and it is unknown whether older patients achieve similar results as younger patients in terms of survival benefit and tolerability. In addition, there are few studies specifically designed for patients over 65 years. Subset analyses of...

BACKGROUND Inflammatory myofibroblastic tumors are rare in the pediatric population. Most common localizations were reported in the lungs. A localization in the pancreas needs differentiation from other tumors and chronic pancreatitis. Treatment is surgical resection, although there are reports of treatment with oral steroids and radiation therapy. CASE REPORT A 6-month-old child was treated ...