Clostridium difficile is the most commonly associated cause of antibiotic associated disease (AAD), which caused ∼21,000 cases of AAD in 2011 in the U.K. alone. The golden Syrian hamster model of CDI is an acute model displaying many of the clinical features of C. difficile disease. Using this model we characterised three clinical strains of C. difficile, all differing in toxinotype; CD1342 (Pa...

OBJECTIVES As an initial step in developing novel antibacterials against Burkholderia pseudomallei, we have characterized the FabI enoyl-ACP reductase homologues in the type II fatty acid biosynthesis pathway from this organism and performed an initial enzyme inhibition study. METHODS A BLAST analysis identified two FabI enoyl-ACP reductase homologues, bpmFabI-1 and bpmFabI-2, in the B. pseud...

This paper describes a corpus of conversations recorded using an extension of the DiapixUK task: the Diapix Foreign Language corpus (DIAPIX-FL) . English and Spanish native talkers were recorded speaking both English and Spanish. The bidirectionality of the corpus makes it possible to separate language (English or Spanish) from speaking in a first language (L1) or second language (L2). An acous...

Tables show the results of the classifiers for the SFM and the FFDM datasets using a 10-fold crossvalidation and the complete dataset, with 20 features selected by the inter/intra cluster criteria and with 20 features of the PCA. Noelia Vállez1,2, Gloria Bueno1, Oscar Déniz-Suárez1, José A. Seoane2, Julián Dorado2, and Alejandro Pazos2 1 VISILAB, E.T.S.I.I, Universidad de Castilla-La Mancha, Sp...

The paper presents the problem of choosing the representatives in an assembly when the whole electoral region is subdivided into electoral districts. Because of the two dimensions, geographical (districts) and political (parties), the problem is called bi-apportionment. Often the allocation of seats to districts is pre-determined and furthermore distorted —meaning that the ratios of the number ...

Abstract Background Repaired tetralogy of Fallot patients develops postoperative complications that are in need for follow-up and re-intervention some circumstances. CMR myocardial feature tracking is a novel method allows quantification bi-atrial bi-ventricular mechanics deformation. So our aim to assess the added value cardiac magnetic resonance imaging its advanced analysis evaluation repair...

There is a strong correlation between relative mammographic breast density and the risk of developing breast cancer. As such, accurately modelling the percentage of a mammogram that is dense is a pivotal step in density based risk classification. In this work, a novel method based on manifold learning is used to segment high-risk mammograms into density regions. As such, finer details are prese...

Mass abnormality segmentation is a vital step for the medical diagnostic process and is attracting more and more the interest of many research groups. Currently, most of the works achieved in this area have used the Gray Level Co-occurrence Matrix (GLCM) as texture features with a region-based approach. These features come in previous phase for segmentation stage or are using as inputs to class...

Elliptic curves find numerous applications. This paper describes a simple strategy to speed up their arithmetic in right-to-left methods. In certain settings, this leads to a non-negligible performance increase compared to the left-to-right counterparts.

(Bi0.5Na0.5)TiO3 (BNT)-based lead-free piezoceramics exhibit excellent electric field-induced strain (electrostrain) properties, but often suffer from large hysteresis and poor fatigue resistance, which strongly limit their applications. Here, &lt;00l&gt; textured Nb5+-doped 0.8(Bi0.5Na0.5)TiO3–0.2(Bi0.5</s...