O6-Benzylguanine (BG) inactivates O6-alkylguanine-DNA alkyltransferase (AGT), resulting in an increase in the sensitivity of cells to the toxic effects of O6-alkylating agents. BG significantly enhances the cytotoxicity and decreases the mutagenicity of nitrogen mustards [i.e., phosphoramide mustard (PM), melphalan, and chlorambucil], a group of alkylating agents not known to produce O6-adducts...

The proinflammatory cytokine interleukin-6 (IL-6) may modulate the onset and progression of complications of diabetes. As this cytokine increases after exercise, and many other exercise responses are altered by prior glycemic fluctuations, we hypothesized that prior hyperglycemia might exacerbate the IL-6 response to exercise. Twenty children with type 1 diabetes (12 boys/8 girls, age 12-15 yr)...

Patients with Type I Diabetes (T1D) must take insulin injections to prevent the serious long term effects of hyperglycemia – high blood glucose (BG). These patients must also be careful not to inject too much insulin because this could induce hypoglycemia (low BG), which can be fatal. Patients therefore follow a “regimen” that, based on various measures, determines how much insulin to inject at...

INTRODUCTION In critical illness, the association of hypoglycemia, blood glucose (BG) variability and outcome are not well understood. We describe the incidence, clinical factors and outcomes associated with an early hypoglycemia and BG variability in critically ill patients. METHODS Retrospective interrogation of prospectively collected data from the Australia New Zealand Intensive Care Soci...

The ability of O-benzylguanine (BG) to inactivate alkyltransferase (AGT) to potentiate the antitumor efficacy of 1,3-bis(2-chloroethyl)-1nitrosourea (BCNU) is being tested in clinical trials. As of now, there are no examples of acquired resistance to BG BCNU in the clinical setting. However, we hypothesized that genetically unstable tumors might develop resistance to the combination after repea...

Given an arbitrary group G we construct a semigroup of idempotents (band) BG with the property that the free idempotent generated semigroup over BG has a maximal subgroup isomorphic to G. If G is finitely presented then BG is finite. This answers several questions from recent papers in the area.

BACKGROUND A novel injectable cement composed of chitosan-bonded borate bioactive glass (BG) particles was evaluated as a carrier for local delivery of vancomycin in the treatment of osteomyelitis in a rabbit tibial model. MATERIALS AND METHODS The setting time, injectability, and compressive strength of the borate BG cement, and the release profile of vancomycin from the cement were measured...

where D is some small category, F is a functor from D to the category of spaces, and, for each object d of D, F (d) has the homotopy type of BH for some subgroup H of G. An expression like 1.1 is sometimes called a homology approximation to BG or a homology decomposition of BG, and can be used either to make calculations with BG or to prove general theorems about BG by induction. (Of course an ...

Microbiological diagnosis of nosocomial candidemia is negatively affected by suboptimal culture yield. Alternative methods are not fully reliable as an aid in candidemia diagnosis. Recently, the detection of (1,3)-β-D-glucan (BG) has been shown to be very promising in this setting. We carried out a prospective study on the clinical usefulness of BG detection in early diagnosis of candidemia. BG...