background: patients with transfusional iron overload have depended on iron chelation therapy and improving chelation regimens have been of the highest priority. the aim of this study was to compare effect of combined versus monotherapy with deferoxamine (dfo) and deferiprone (dfp) in iron overloaded beta thalassemia (bt) major patients materials and methods we studied 36 bt major patients (mea...

background thalassemia is among the most common hematological diseases, but it has no definitive cure. the self-concept in adolescents with thalassemia major changes due to changes in their facial form. among the factors affecting the patient’s self-concept is social capital. objectives the study aims to examine the relationship between social capital and self-concept in adolescents with thalas...

BACKGROUND Patients with beta thalassemia suffer from increased susceptibility to infections and putridity plays a major role in the patient's morbidity and mortality. The risk of transfusion-transmitted viral infection is well known in these patients. However, there is dearth of information about the seroprevalence of herpes simplex virus (HSV) infection in patients with beta thalassemia in li...

We have identified two individuals of Greek Cypriot origin with thalassemia intermedia. Molecular analysis has shown that each individual is a compound heterozygote for a previously described beta zero thalassemia allele and a novel mutation, C-->G in position +33, in the 5' untranslated region of the beta globin gene. In both families the beta +33 allele is associated with the same beta haplot...

Synthesis of globin chains in bone the heterozygotes, there was a signifimarrow and peipheral blood samples cant defect in beta synthesis in the from a black family with mild beta peripheral blood of white subjects, thalassemia was compared with simiwhile in two of three black patients the lar studies in white people. Blood and P/ ratio was in the normal range. Albone marrow were incubated with...

BACKGROUND Thalassemia is the most common monogenic disease in South-East of Iran. Despite the 70% reduction in Iranian thalassemia cases after thalassemia control comprehensive program, 601 affected babies were born in Sistan and Balouchistan Province, Iran from 2002 to 2010, so this study aims at investigating the causes of new thalassemia cases. METHODS Data from this retrospective cross-s...

Abstract A group of inherited blood defects is known as Thalassemia among the world’s most prevalent hemoglobinopathies. Thalassemias are two types such Alpha and Beta Thalassemia. The cause these gene mutations leading to low levels and/or malfunctioning ? ? globin proteins, respectively. In some cases, one proteins may be completely absent. chains form a fold or pocket for heme (Fe++) attachm...

In order to study the role of the cytokine interleukin-3 (IL-3) and its signaling pathways in erythropoiesis of beta-thalassemia/HbE erythroid progenitor cells, CD34 positive cells were isolated from peripheral blood of patients and healthy subjects. After culturing the cells in the presence or absence of IL-3, cell viability was measured by trypan blue staining and apoptotic cells were analyze...

Korea is in the low-prevalence area of beta-thalassemia and the Korean population has relatively homogenous racial characteristics. Recently, we identified some causative mutations of the Korean beta-thalassemia patients. In order to elucidate the genetic background of beta-thalassemia alleles in Koreans, we determined the restriction fragment length polymorphism (RFLP)-haplotype and framework ...