The oxidative stress status of the transfusion-dependent Ebeta- and beta-thalassemia patients were studied before and after treatment with vitamin E for a period of four weeks. The level of cellular vitamin antioxidants viz. ascorbic acid and vitamin E in the thalassemia patients were found to be considerably lower compared to normal subjects. The activities of enzymatic antioxidants viz. catal...

background: beta-thalassemia patients have a high prevalence for hepatitis c virus (hcv) infection. in developing countries, hcv antibody is reported to be high in this group of patients. this study aims to determine the distribution of hcv amongst beta-thalassemia patients in northern iran. materials and methods: this study was undertaken from october 2010 to june 2011 on 245 beta-thalassemia ...

background: major thalassemia is an autosomal recessive disease with complications, mortality and serious pathology. today, the life expectancy of patients with major thalassemia has increased along with therapeutic advances. therefore, they need lifelong care, and caring for them would incur many costs. being aware of the patients’ costs can be effective for controlling and managing the costs ...

background heart failure is a major cause of death in thalassemia. the study aimed to determine the diagnostic value of n terminal pro b type natriuretic peptide (nt-pro bnp), to early diagnose the cardiac involvement in beta- thalassemia major patients. materials and methods  80 thalassemia patients aged 7 to 18 years old (patients group), and 80 healthy age and gender matched controls were en...

from 1996 to 2002, fifty three patients with major beta-thalassemia received allogeneic peripheral blood stem cell trans plantation (pbsct). median age was 6 years .twenty two were class i, 17 class ii and 14 class iii. all of the donors were hla-identical. conditioning regimen for class i and ii patients consisted of cyclophosphamide (cy) 50 mg/kg/day for 4 days + busulfan (bu) 3.5 mg/kg for 4...

Background: Screening and counselling is the most effective way to prevent the birth of children with thalassemia major. An accurate and relatively less time-consuming protocol is necessary to screen large populations. Separating iron deficiency anaemia from thalassemia trait based on blood cell parameters has been used by hematologists for many years. We aimed to design a new approach to scree...

Beta-thalassemia is due to a defect in the synthesis of the beta-globin chains, leading to alpha/beta imbalance, ineffective erythropoiesis, and chronic anemia. The spectrum of thalassemias is wide, with one end comprising thalassemia minor, which consists of a mild hypochromic microcytic anemia with no obvious clinical manifestations, while on the other end is thalassemia major, characterized ...

Background: Retarded growth in thalassemic patient is complex and multi-factorial, it includes chronic hypoxia secondary to anemia when pre-transfusion haemoglobin below 9 g/dl. Development of sexual characteristics children markedly delayed as compared their non-thalassemic siblings the expected development criteria due iron overload. The main objective present study monitor these patients lon...

3. Taher A, Isma'eel H, Cappellini MD. Thalassemia intermedia: revisited. Blood Cells Mol Dis 2006;37:12-20. 4. Huehns ER, Dance N, Beaven GH, Heclht F, Motulsky AG. Human embryonic hemoglobins. Cold Spring Harb Symp Quant Biol 1964;29:327-31. 5. Villegas A, Ropero P, González FA, Anguita E, Espinós D. The thalassemia syndromes: molecular characterization in the Spanish population. Hemoglobin 2...