The metabolism of irbesartan, a highly selective and potent nonpeptide angiotensin II receptor antagonist, has been investigated in humans. An aliquot of pooled urine from healthy subjects given a 50-mg oral dose of [14C]irbesartan was added as a tracer to urine from healthy subjects that received multiple, 900-mg nonradiolabeled doses of irbesartan. Urinary metabolites were isolated, and struc...

objective: maternal type and amounts of dietary fatty acids affect on reproductive process in the mice. the present study investigated the effects of maternal supplementation with different amounts of omega-6 or omega-9 during pregnancy on the number of offspring, sex-ratio and duration of gestation. materials and methods: eight-week-old female c57bl/6 mice were randomly assigned into four diet...

background: omega 3 and vitamin e are two critical nutrients which include beneficial effects in coronary artery disease (cad). the aim of this study was to assess the effects of omega 3 alone supplementation or in combination with vitamin e on serum glucose and lipid levels and insulin resistance in cad patients. methods: participants of this clinical trial included 60 male patients with cad w...

Introduction and Aim: Gestational diabetes mellitus (GDM) involves insulin resistance, altered levels of adipocytokines inflammation. Interaction various molecules in the pathogenesis obesity resistance plays a major role GDM. Angiopoietin-like protein 8, also named betatrophin is hormone which synthesized from liver adipocytes. This molecule has beta cell-regenerating effect proposed to have t...

The grand partition function for a long linear system of alternating alpha and beta sequences with the restraint of a fixed number, N(alphabeta), of alphabeta boundaries depends in an extremely simple way on the alpha-sequence and beta-sequence grand partition functions, xi(alpha) and xi(beta). When the restraint is removed, we have mualphabeta = 0, where mualphabeta is the chemical potential c...

A two-layer spherical alpha2 dynamo model consisting of an inner electrically conducting core (magnetic diffusivity lambdai and radius ri) with alpha=0 surrounded by an electrically conducting spherical shell (magnetic diffusivity lambdao and radius ro) with a constant alpha is shown to exhibit oscillatory behavior for values of beta=lambdai&solm0;lambdao and ri&solm0;ro relevant to the solar d...

In this paper we demonstrate that RNA sequences present upstream and downstream of a reporter gene coding region play an important role in determining the amount of protein produced from an mRNA. A translational enhancer, omega, derived from tobacco mosaic virus, when present at the 5'-end of beta-glucuronidase mRNA increased the efficiency of translation 16-fold to 18-fold in electroporated to...

(1) Effects of dietary treatment of male albino rats with eicosapentaenoic acid (EPA) or docosahexaenoic acid on hepatic mitochondrial lipid metabolism have been investigated. (2) Mitochondria isolated from rats given these treatments were shown to have increased ability to respire on acyl-CoA esters in the presence of malonate. This effect was expressed with most of the long-chain acyl-CoA est...

Nebivolol is a recently developed beta-blocker provided with vasodilator properties. Because the mechanism of the putative endothelium-dependent effect of this beta-adrenoceptor blocker has not been completely elucidated, the aim of this study was to investigate the effects of nebivolol on an isolated resistance vascular bed and on cell messengers and constitutive nitric-oxide synthase activity...