We investigated systematically the effects of Tet-induced oxidation products of 5-methylcytosine on Dnmt1- and DNMT3a-mediated cytosine methylation in synthetic duplex DNA. We found that the replacement of 5-methylcytosine at a CpG site with a 5-hydroxymethylcytosine, 5-formylcytosine, 5-carboxylcytosine or 5-hydroxymethyluracil resulted in altered methylation of cytosine at both the opposite a...

The gravity field of the Solar System celestial bodies is generally estimated within orbit determination process probes visiting them. Low altitude, high inclination and near circular orbits are best suited for this purpose. As part a global characterization effort Jovian moon Europa, we studied influence multiple orbital parameters configurations on recovery its parameters. We made use Repetit...

the least squares harmonic estimation is applied to the hourly time-series of total electron contents (tec) derived from ionospheric models using seven years of gps observations processed by bernese software. the frequencies of dominant spectral components in the spectrum are estimated. we observe significant periodic patterns with periods of 24 h and its fractions 24h/n, n=2,…,11, which are th...

© 2017 The Author(s). Published by Taylor & Francis on behalf of the Nordic Orthopedic Federation. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (https://creativecommons.org/licenses/by-nc/3.0) DOI 10.1080/17453674.2016.1272375 Neglected traumatic dislocations of the hip are rarely seen in high-income countries, and the mod...

The typical dysplastic hip joint is characterised by maldirection of the acetabulum and femoral neck, insufficient coverage of the femoral head focally and globally and erosions of the limbus acetabuli (1). An unknown number of persons with hip dysplasia will suffer from pain in hip or groin, decreased hip function and development of osteoarthritis at a young age. The Bernese periacetabular ost...

Gently sloping surfaces for settlement are scarce in high mountains ranges and they are commonly related to distal parts of alluvial fans where floods hazards can be expected. To understanding the influence of external factors, such as climatic variability and land uses, on the alluvial fan accretion and flooding processes, sedimentology and pollen analysis from local site provide valuable data...

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