The enzyme 4-chlorobenzoate-CoA dehalogenase catalyzes the hydrolysis of 4-chlorobenzoate-CoA (4-CBA-CoA) to 4-hydroxybenzoyl-CoA (4-HBA-CoA). In order to facilitate electrophilic catalysis, the dehalogenase utilizes a strong polarizing interaction between the active site residues and the benzoyl portion of the substrate [Taylor, K. L., et al. (1995) Biochemistry 34, 13881]. As a result of this...

Amounts of isothiocyanates and related compounds in a mustard extract and a horseradish extract for food additive use were determined by GC, after confirmation of the identity of GC peaks by GC/MS. Amounts of allyl isothiocyanate, which included that of allyl thiocyanate, because most of the allyl thiocyanate detected in the sample was assumed to have been formed from allyl isothiocyanate durin...

Sandra M. Duval Mark A. Berhow New Crops and Processing Technology Research, USDA, ARS, National Center for Agricultural Utilization Research, 1815 North University Street, Peoria, IL 61604 Defatted seedmeals from 15 glucosinolate-containing plant species were analyzed for herbicidal activity by determining inhibition of seedling emergence when added to a sandy loam soil containing wheat and si...

The fumigant toxicity of various essential oils and selected monoterpenoid components were tested against the adult German cockroach, Blattella germanica (L.) (Dictyoptera: Blattellidae). Responses varied according to plant material, concentration, and exposure time. High insecticidal activity against adult B. germanica specimens was achieved with allyl isothiocyanate (component of horseradish)...

the effect of phenylen di-isothiocyanate (jonit) in the mass treatment of various intestinal helminthiases was evaluated among the inhabitants of a village in dezful, southwest iran. stool samples collected and examined from 17 persons showed infection rates of 80% for ancylostoma duodenale, 57.3% for ascaris, 46.7% for trichostronylus spp. and 22.8% for h. nana.seventy- one persons (41 childre...

Tropaeolum majus L. is an annual herbaceous plant and a member of the Tropaeolaceae family, which belongs to Brassicales order. It excellent source flavonoids, carotenoids, phenolic acids, vitamin C, it that contains glucosinolate glucotropaeolin. The major degradation product glucotropaeolin benzyl isothiocyanate known for its various biological activities. In this study, essential oil was iso...

Cruciferous vegetables, such as Brassica, which contain substantial quantities of glucosinolates, have been suggested to possess anticarcinogenic activity. Cutting and chewing of cruciferous vegetables releases the thioglucosidase enzyme myrosinase, which degrades glucosinolates to isothiocyanates and other minor metabolites. Cooking of cruciferous vegetables inactivates the myrosinase enzyme, ...

The title mol-ecule, C26H16O2, crystallizes as a mol-ecular crystal with no strong inter-molecular inter-actions (the shortest C-H⋯O contact is longer than 3.4 Å). Two flat ace-naphthyl-ene groups of neigboring 1,2-di-benzoyl-ace-naphthyl-ene mol-ecules are related by a crystallographic center of symmetry and are stacked with the distance between their mean planes of 3.37 (1) Å, apparently maki...

the n-(2-benzoyl-phenyl) oxalyl derivatives are important models for studying of three-centered intramolecular hydrogen bonding in organic molecules. the quantum theoretical calculations for two crystal structures of n-(2-benzoyl-phenyl) oxalyl (compounds i and ii) were performed by density functional theory (b3lyp method and 6-311+g* basis set). from the optimized structures, geometric paramet...

reaction of 2-hydrazinocarbonyl-3-chloro-5-phenoxy-benzo[b] thiophene with different substituted phenyl isothiocyanate gave n-substituted arylthiosemi-carbazide derivatives (1a-h). 1,3,4-thiadiazole derivatives (2a-h) were prepared by the cyclization of arylthiosemicarbazides (1a-h) with concentrated sulphuric acid. all the compounds were screened for their antitubercular activity against mycob...