Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) and coxibs are traditional medicines for the treatment of inflammation, yet associated with serious side effects. Hence, need discovering novel compounds valuable clinical benefits is great importance. In this study, 18 derivatives p-nitrophenyl hydrazones were docked against COX-2, 5-LOX, H+/K+ ATPase, followed by predicting their drug-lik...

Schiff bases of Benzene sulfonyl hydrazide (SBSZ) (1a-e) were prepared by using various benzaldehyde derivatives. SBSZ then condensed with mercapto acetic acid. The obtained resultant 2-thiazolidinone derivatives (2a-e) 5-nitro-2furfuralidine i.e. (Z)-N-(5-((5-nitrofuran-2-yl) methylene)-4-oxo-2-substitutedthiazolidin-3-yl) benzenesulfonamide (3a-e). These further phenyl urea to yield fused het...

This report describes a method for patterning ligands onto mixed SAMs of alkanethiolates on gold by microcontact printing (μCP). The mixed SAMs were made from thiols presenting terminal tri(ethylene glycol) groups (HS(CH2)11(OCH2CH2)3OH, 1) and terminal hexa(ethylene glycol)-CH2CO2H groups (HS(CH2)11(OCH2CH2)6OCH2CO2H, 2). Ligands were printed using a two-step procedure. The carboxylic acid gro...