OBJECTIVE The right to vote can be abrogated when persons become incompetent to cast a ballot. This applies particularly to people with Alzheimer's disease, who at some point will lose capacity. A 2001 federal court decision offered the first clear criteria ("Doe voting capacity standard") for determining voting competence, focused on understanding the nature and effect of voting and on the abi...

Formulating appropriate storage conditions for biopharmaceutical proteins is essential for ensuring their stability and thereby their purity, potency, and safety over their shelf-life. Using a model murine IgG3 produced in a bioreactor system, multiple formulation compositions were systematically explored in a DoE design to optimize the stability of a challenging antibody formulation worst case...

Fecal corticosterone concentration (FCC) is increasingly being used as a noninvasive indicator of stress in assessment of nonhuman animal welfare. The aim of this study was to evaluate effects of breed, cage type, reproductive phase, and their interactions on FCC levels in doe rabbits. A total of 252 doe rabbits were randomly assigned to 2 groups. Does were individually housed in either standar...

Assurance requirements were included in the disposal regulations to compensate in a qualitative manner for the inherent uncertainties in projecting the behavior of natural and engineered components of the repository for many thousands of years (50 FR 38072). Section 194.44 is one of the assurance requirements in the Compliance Criteria. Section 194.44 implements the assurance requirement at Sec...

In this study, we propose an organic solvent-free, one-step mechanochemistry approach to engineer water-dispersible graphene oxide/superparamagnetic iron oxide (GO/SPIOs) hybrids, for biomedical applications. Although mechanochemistry has been proposed in the graphene field for applications such as drug loading, exfoliation or polymer-composite formation, this is the first study to report mecha...

Design of experiment (DoE) techniques are invaluable tools which readily allow for efficient optimisation processes via simultaneous evaluation a combination input parameters. Such approaches can yield positive outcomes whilst minimising the number resources and amount time utilised, hence, achieving more robust approach. Additionally, when designing intelligently information about interaction ...

s and Oral Presentations 17 Journal Publications 18 Other DOE Research Published During Contract Period 18