Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), such as gefitinib, have been demonstrated to effectively treat the patients of extracranial non-small cell lung cancer (NSCLC). However, these patients often develop brain metastasis (BM) during their disease course. The major obstacle to treat BM is the limited penetration of anticancer drugs across the blood-brain barri...

L eft ventricular assist devices (LVADs) are an established treatment for patients with end-stage heart failure as either a bridge to cardiac transplantation 1 or as lifelong support, also known as destination therapy.) is a continuous flow device that was approved by the US Food and Drug Administration in 2008, after a pivotal trial in 133 patients awaiting transplantation. 3 More patients hav...

DNA bending induced by six DNA (cytosine-5) methyltransferases was studied using circular permutation gel mobility shift assay. The following bend angles were obtained: M.BSP:RI (GG(m5)CC), 46-50 degrees; M.HAE:III (GG(m5)CC), 40-43 degrees; M.SIN:I (GGW(m5)CC), 34-37 degrees; M.SAU:96I (GGN(m5)CC), 52-57 degrees; M.HPA:II (C(m5)CGG), 30 degrees; and M.HHA:I (G(m5)CGC), 13 degrees. M. HAE:III w...

Fast-starts associated with escape responses were studied in short-horn sculpin (Myoxocephalus scorpius L.), ranging from 5.5 to 32 cm in total length (L). Electromyography and sonomicrometry were used simultaneously to measure muscle activation and length changes, respectively, in the superficial layers of fast muscle in rostral myotomes. Escape responses consisted of a half tailbeat to bend t...

Conveying hard and the abrasive materials has been one of the major operational problems in industrial situations. The erosion of plant components, especially the pipe bends by abrasive solid particles of a fluid stream makes installation of pneumatic conveying systems a very costly affair for industry. Most users have either lived with the problem or have employed expensive bend materials to r...

We report the measurement of small losses in transmission line (TL) components intended for high-power millimeter-wave applications. Measurements were made using two different low-power techniques: a coherent technique using a vector network analyzer (VNA) and an incoherent technique using a radiometer. The measured loss in a 140 GHz 12.7 mm diameter TL system, consisting of 1.7 m of circular c...

During inversion of a Volvox embryo, a series of cell shape changes causes the multicellular sheet to bend outward, and propagation of the bend from the anterior to the posterior pole eventually results in an inside-out spherical sheet of cells. We use fluorescent and electron microscopy to study the behavior of the cytoskeleton in cells undergoing shape changes. Microtubules are aligned parall...

Here we summarize the DNA bend sites in a 66-kb region of the human beta-globin locus. A total of 98 sites were mapped by circular permutation assay along the locus with an average interval of 679.2 +/- 229.6 bp between them. The distribution of the bend sites indicated that although the most frequent distance was about 650-700 bp, there appeared to be preferences at 300-400, 500-550, 800-850, ...

A molecular theory of both elastic constants and the flexoelectric coefficients of bent-core nematic liquid crystals has been developed taking into account dipole-dipole interactions as well as polar interactions determined by the bent molecular shape. It has been shown that if polar interactions are neglected, the elastic constants are increasing monotonically with the decreasing temperature. ...