Experiment Design – Response Surface Methodology (RSM) is used to model and to optimize the activation of Methane (C1) using Ethane (C2) as co-reactant into higher hydrocarbons, over Zn-containing zeolite catalyst. The application of this methodology in this work, allows a better understanding of the influence of the different factors; on two responses simultaneously: C1 Conversion and Aromatic...

a-Galactosidase production by a novel actinomycete strain Streptomyces griseoloalbus in shake flask culture was optimized using response surface methodology. Screening of variables to find their relative effect on a-galactosidase production was done using Plackett-Burman design. Out of the eleven factors screened, salinity, magnesium sulphate and temperature were found to influence the enzyme p...

Biodiesel manufacturing from renewable feedstocks has received a lot of attention as viable alternative to fossil fuels. The Box-Behnken design, analysis variance (ANOVA), and the Grey Wolf Optimizer (GWO) algorithm were used in this work optimise biodiesel production Nahar oil. goal was determine best operating parameters for maximising yield. design is used, with four essential taken into acc...

Objective: To develop a Verapamil hydrochloride controlled release gastro-retentive (CRGR) tablet for once-daily dosing using the response surface Box-Behnken Design (BBD) approach improvement of bioavailability and reduction in frequency to overcome issues related conventional formulation. Methods: For optimization, 33Box-Behnken design was used. The independent variables were selected, amount...

A series of drug-in-adhesive transdermal drug delivery systems (patch) with different chemical penetration enhancers were designed to deliver drug through the skin as a site of application. The objective of our effort was to study the influence of various chemical penetration enhancers on skin permeation rate and adhesion properties of a transdermal drug delivery system using Box-Behnken experi...

Subcritical water extraction (SWE) of Inonotus Obliquus polysaccharides (IOP) was investigated using response surface methodology (RSM) with a design by Box–Behnken design (BBD). Results showed that the optimum SWE conditions for IOP production were as follows: extraction temperature 194°C, residence time 5.36 min and liquidsolid ratio 53 mL/g, yielding 168.80 ± 0.59 mg/g of IOP, which was in c...