to malignant melanoma. The exact cause is unknown. There may be hereditary factors, autosomal dominance or other multifactor determinants. Management depends upon size, location and malignant transformation. Surgical excision is the mainstay of treatment. Cultured epidermal autograph has been used successfully to cover postoperative large surface area defect. We report a one-day-old male child ...

Papillomatous Compound Nevus An 8-year-old boy was observed for 5 years for an enlarging, pigmented lesion on his left lower lid (Fig 1). An excisional biopsy was performed and histopathology (H&E) revealed skin with keratinized, stratified squamous epithelium in a papillomatous configuration (Figs 2 and 3). The lesion had nests of densely pigmented melanocytes within the epithelium (black arro...

Differentiation of a melanocytic nevus and melanoma is often a dilemma clinically as well as histologically. This dilemma involves inexperienced as well as knowledgeable pathologists. The provoking question turns out to be: why is this differential diagnosis often a quandary? The answer lies in the fact that there are overlapping cytological and architectural criteria used interchangeably for a...

We report phakomatosis pigmentovascularis (PPV) detected in a 40- year-old male characterized by the presence of a port-wine stain in the background of aberrant Mongolian spots covering the back, nevus of Ota, ocular melanosis, epidermal nevus and a scaly patch with the diagnosis of discoid lupus erytematosus. These associations have not been reported yet.

neous biopsies, yielding 69 collision tumors. Cascajo and colleagues found 54 collision tumors of malignant cutaneous neoplasms associated with seborrheic keratoses in 85,000 biopsies. The most common combinations found by Boyd and Rapini included basal cell carcinoma and nevus (14), basal cell carcinoma and seborrheic keratosis (8), nevus and seborrheic keratosis (14), actinic keratosis and ne...

OBJECTIVE To determine the frequency of and the histologic and clinical factors associated with melanoma existing in histologic contiguity with a nevus. DESIGN Pathology reports from melanomas collected from January 1, 1993, to December 31, 1997, were retrospectively reviewed. SETTING Independent, community-based dermatopathology laboratory. PATIENTS A total of 1606 patients with a histol...

OBJECTIVE To achieve a clinicopathologic classification of Spitz nevi by comparing their clinical, dermoscopic, and histopathologic features. DESIGN Eighty-three cases were independently reviewed by 3 histopathologists and preliminarily classified into classic or desmoplastic Spitz nevus (CDSN, n = 11), pigmented Spitz nevus (PSN, n = 14), Reed nevus (RN, n = 16), or atypical Spitz nevus (ASN...

BACKGROUND Little is known about the recurrence/persistence rates of dysplastic nevi (DN) after biopsy, and whether incompletely removed DN should be re-excised to prevent recurrence. OBJECTIVE Our purpose was to determine the recurrence rates of previously biopsied DN, and to assess whether biopsy method, margin involvement, congenital features, epidermal location, and degree of dysplasia ar...

High melanocytic nevus count is a strong predictor of melanoma risk. A GWAS of nevus count in Australian adolescent twins identified an association of nevus count with the interferon regulatory factor 4 gene (IRF4 [p = 6 x 10(-9)]). There was a strong genotype-by-age interaction, which was replicated in independent UK samples of adolescents and adults. The rs12203592(*)T allele was associated w...