Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD) and limb girdle muscular dystrophies (LGMD) represent a significant proportion of paediatric and adult neuromuscular neurology practice. The proactive symptom-based multidisciplinary team (MDT) management and access to non-invasive ventilation have enabled improved survival into adulthood. Nevertheless the severe disability impo...

BACKGROUND Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are X-linked recessive neuromuscular diseases resulting from dystrophin (DMD) gene mutations. It has been known that the carrier of DMD mutations may also have symptoms of the disease. While de novo mutation is quite common in BMD/DMD patients, it is rarely reported in the female carriers. METHODS Two sporadic Ch...

Members of three unrelated families with the mild Becker type of muscular dystrophy were subjected to lymphocyte capping tests and measurements of serum creatine kinase activity. Both tests correctly identified all nine affected males, but only the capping test was abnormal in seven of eight obligate carriers. The number of capped cells in carriers and affected persons with the Becker-type dyst...

OBJECTIVE Duchenne muscular dystrophy is the commonest genetic myopathy but there exist a large number of inherited neuromuscular diseases which individually are very rare and where clinical information is not widely available. This review is based on the author's experience in a pediatric muscle clinic and provides practical guidance and treatment plans for frequently encountered problems. S...

Study of 165 unrelated patients with X linked muscular dystrophy (117 with Duchenne and 48 with Becker dystrophy) has shown nine Duchenne cases (8% of the total) where a molecular deletion was detected using probes pERT87 or XJ1.1. No cytogenetic abnormalities were detectable in this unselected series of patients and no clear clinical or other differences were found between deletion and non-del...

© Springer Science+Business Media New York 2015 S. Grossbard, The Marriage Motive: A Price Theory of Marriage, DOI 10.1007/978-1-4614-1623-4_2 This chapter and the following are adapted from “A Theory of Allocation of Time in Markets for Labor and Marriage,” Economic Journal, Vol. 94, pp. 863–882, December 1984. While writing it I benefited from helpful comments from Gary Becker, Jerry Green (f...

More than 60% of Duchenne/Becker muscular dystrophy (DMD/BMD) cases is due to deletions in the dystrophin gene, therefore the large majority of female carriers is heterozygote for an intragenic deletion. A new protocol is presented here for detection of these heterozygotes, based on multiplex semi-quantitative PCR amplification of genomic DNA. The method is non-radioactive, fast and easy to per...