For proton spot scanning, use of a real-time-image gating technique incorporating an implanted marker and dual fluoroscopy facilitates mitigation of the dose distribution deterioration caused by interplay effects. This study explored the advantages of using a real-time-image gating technique, with a focus on prostate cancer. Two patient-positioning methods using fiducial markers were compared: ...

This study investigated radiation dose variations in pre-clinical irradiation due to the photon beam energy and presence of tissue heterogeneity. Based on the same mouse computed tomography image dataset, three phantoms namely, heterogeneous, homogeneous and bone homogeneous were used. These phantoms were generated by overriding the relative electron density of no voxel (heterogeneous), all vox...

In this paper, we explore the potentialities of using ultrasound waves as a post-irradiation treatment after proton beam writing (PBW) patterning PTFE. To that end, 2-mm-thick foils PTFE were irradiated with 2.2 MeV protons an average current 50 pA. Straight line structures patterned on polymer 3.5 × μm2 focused beam. Post-irradiation polymers placed in heat bath at 60 °C and immersed either di...

Heavy-ion beam irradiation is one of the principal methods used to create mutants in plants. Research on mutagenic effects and molecular mechanisms of radiation is an important subject that is multi-disciplinary. Here, we re-sequenced 11 mutagenesis progeny (M3) Arabidopsis thaliana lines derived from carbon-ion beam (CIB) irradiation, and subsequently focused on substitutions and small inserti...

We study ion-irradiation-induced electrical isolation in n-type single-crystal ZnO epilayers. Emphasis is given to improving the thermal stability of isolation and obtaining a better understanding of the isolation mechanism. Results show that an increase in the dose of 2 MeV O ions ~up to ;2 orders of magnitude above the threshold isolation dose! and irradiation temperature ~up to 350 °C) has a...

The spatial energy distributions of beams of protons accelerated by ultrahigh intensity (>10(19)Wcm2) picosecond laser pulse interactions with thin foil targets are investigated. Using separate, low intensity (<10(13)Wcm2) nanosecond laser pulses, focused onto the front surface of the target foil prior to the arrival of the high intensity pulse, it is demonstrated that the proton beam profile c...

At National Institute of Radiological Sciences (NIRS), more than 6500 patients have been successfully treated by carbon-ion beams since 1994. The successful results of treatments have led us to construct a new treatment facility equipped with three-dimensional pencil beam scanning irradiation system. The commissioning of NIRS fast scanning system installed into the new facility was started in S...

Background: Owing to the inability of real-time polymerase chain reaction (PCR) to distinguish between signals originating from viable cells and DNA released from dead cells, (i.e. it can detect dead cells) a risk exists that DNA from dead cells can result in false-positive PCR signals, so it is important to use a proper method for sterilization to maintain the accuracy of the quantitative real...

Angiogenesis is essential for tumor growth and metastasis. Because endothelial cells are genetically stable, they rarely acquire resistance to anticancer modalities, and could, thus, be a suitable target for radiation therapy. Heavy ion radiation therapy has attracted attention as an effective modality for cancer therapy because of its highly lethal effects, but the effects of heavy ion irradia...

BACKGROUND Microbial contamination levels and corresponding sensitivities to gamma rays (GR) and elec- tron beam (EB) irradiation were tested in chamomile (Chamomile recutta L.). METHODS Chamomile powders were treated with 10 and 20 kGy by GR and EB, respectively. Microbiological and chemical analyses were performed on controls and treated samples immediately after irradiation, and after 12 m...