Chronic urethral obstruction and the ensuing bladder wall remodeling can lead to diminished bladder smooth muscle (BSM) contractility and debilitating lower urinary tract symptoms. No effective pharmacotherapy exists to restore BSM contractile function. Neuropilin 2 (Nrp2) is a transmembrane protein that is highly expressed in BSM. Nrp2 deletion in mice leads to increased BSM contraction. We de...

A binder holds powders together to form granules and also provides the cohesiveness required for binding of the granules under compression to form a tablet. Some natural excipients are currently available for pharmaceutical formulation. Aim of this study was to isolate the mucilage from different plants and to evaluate them as a binder. Here an effort was made to investigate the efficacy of muc...

Cigarette smoking is the main risk factor for the development of chronic obstructive pulmonary disease (COPD). However, little is known about the mechanisms of cigarette smoke-induced bronchial smooth muscle (BSM) hyperresponsiveness. In the present study, we investigated the effects of aqueous cigarette smoke extract (ACSE) on the BSM contraction in rats. The bronchial strips of rats were incu...

Galacturonosyltransferase 1 (GAUT1) is an alpha1,4-D-galacturonosyltransferase that transfers galacturonic acid from uridine 5'-diphosphogalacturonic acid onto the pectic polysaccharide homogalacturonan (Sterling et al., 2006). The 25-member Arabidopsis thaliana GAUT1-related gene family encodes 15 GAUT and 10 GAUT-like (GATL) proteins with, respectively, 56-84 and 42-53% amino acid sequence si...

Chia seed mucilage is a polysaccharide capable of forming hydrogels with excellent water-binding capacity due to its physical and chemical properties favorable characteristics for encapsulating protecting valuable hydrophilic molecules in the food, pharmaceutical, cosmetic industries. This research aimed show that mixtures chia sodium alginate used as wall materials encapsulate are suitable. We...

the autotetraploidy was achieved in basil using tip meristem treatment of seedlings with various concentrations of colchicine solution (0, 0.05, 0.1, 0.2, 0.5 and 0.75% (w/v) ph = 6). a significant increase in the essential oil content was observed in tetraploids as they carry the potential of productivity of 69 % more oil over the diploids. a field experiment was conducted to investigate the e...

Coatings that reduce the fat content of fried food are an alternate option to reach both health concerns and consumer demand. Mucilage garden cress (Lepidium sativum) seed extract (MSE) was modified into edible coating with or without ascorbic acid (AA) coat fresh-cut potato strips during cold storage (5 °C 95% RH for 12 days) subsequent frying. Physical attributes such as color, weight loss, t...