A comparative study of the ability of amino-substituted benzo[b]quinolizinium derivatives to act as DNA- or protein-sensitive fluorescent probes is presented. Spectrophotometric titrations, DNA denaturation studies and viscometric titrations showed that all tested aminobenzo[b]quinolizinium derivatives intercalate into DNA with binding constants K(b) = 10(4)-10(5) M(-1). The intense fluorescenc...

An enzyme solution exerting this activity is easily and conveniently prepared from the soy bean (Glycine hispida).4 By extracting the ground tissue with acidified water and filtering, a perfectly clear solution is obtained which under proper precautions can be preserved for a considerable length of time. A solution in which urea is to be determined is treated with a portion of this extract and,...

Quantifying the amount of carbon dioxide (CO2) in seawater is an essential component of ocean acidification research; however, equipment for measuring CO2 directly can be costly and involve complex, bulky apparatus. Consequently, other parameters of the carbonate system, such as pH and total alkalinity (AT), are often measured and used to calculate the partial pressure of CO2 (pCO2) in seawater...

Supramolecular self-assembly offers a powerful strategy to produce high-performance, stimuli-responsive nanomaterials. However, lack of molecular understanding of stimulated responses frequently hampers our ability to rationally design nanomaterials with sharp responses. Here we elucidated the molecular pathway of pH-triggered supramolecular self-assembly of a series of ultra-pH sensitive (UPS)...

The quantity most directly related to the net charge or valence of corpuscular proteins is the electrophoretic mobility. In 1932 Abramson (1) showed that in solutions of the same ionic strength the electric mobility of the same protein at different hydrogen ion activities is directly proportional to the number of hydrogen ions bound or released as determined by titration curves. His comparisons...

The Mobile Insulin Titration Intervention (MITI) for Insulin Glargine Titration in an Urban, Low-Income Population: Randomized Controlled Trial TITLE 1a-i) Identify the mode of delivery in the title Yes, the study uses mobile phones. "The Mobile Insulin Titration Intervention (MITI) for Insulin Glargine Titration in an Urban, Low-Income Population: Randomized Controlled Trial" 1a-ii) Non-web-ba...

Clozapine is often considered the gold standard for the treatment of schizophrenia. Clinical guidelines suggest a gradual titration over 2 weeks to reduce the risks of adverse events such as seizures, hypotension, agranulocytosis, and myocarditis. The slow titration often delays time to therapeutic response. This raises the question of whether, in some patients, it may be safe to use a more rap...