To elucidate the mechanisms underlying acetylcholinesterase (AChE) localization, we analyzed the distribution of AChE and Ache mRNA during myogenesis in cocultures of human muscle and fetal rat spinal cord. We observed a temporal coincidence in alterations of AChE localization and nuclei expressing the message, suggesting developmental regulation at the mRNA level. Nonuniform mRNA staining amon...

In the present study, ultrastructural alterations induced by oral administration of imidacloprid over 4 weeks was assessed in rats. Forty eight male sprague dawley rats procured from NIN and divided into four groups. Group 1 given with basal diet, group 2 orally gavaged with 80mg/kg/day imidacloprid, group 3 was treated with vitamin C at the rate of 10 mg/kg b.wt/day and group 4 was treated wit...

The condition of dominance or submission following agonistic encounters in the adult male mouse is known to differentially affect brain nerve growth factor, a neurotrophin playing a role in brain remodeling, in the fine tuning of behaviour and in the regulation of the basal forebrain cholinergic neurons. During development and adult life nerve growth factor regulates brain expression of neurotr...

Introduction: While much work has been devoted to MRI-based segmentation and voxel-based morphometry (VBM) of cortical anatomy, comparatively few studies have investigated deep grey matter structures. These are of particular interest for study of the structural correlates of neurological and neuropsychiatric disorders associated with basal ganglia dysfunction (1). The relatively small number of...

PCNA and esophagin have been implicated in the multistep process of carcinogenesis, but simultaneous characterization of these proteins in the early stages of esophageal neoplastic progression has yet to be undertaken. In morphologically normal esophageal epithelium, esophagin stains the granular layer cells, principally in their cell membrane portions. PCNA, in contrast, stains the nuclei of c...

Cytoplasmic alterations in human epidermis irradiated with ultraviolet light have been described by light microscopy (1, 2). Pronounced changes occurred in cells of the basal and spinous layers at the peak of the erythema reaction (twenty-four to thirty hours after irradiation). At this time, cells in the spinous layer developed homogeneous, deeply staining cytoplasm and pyknosis of nuclei. Tbe...

BACKGROUND AND PURPOSE In a large number of patients with Leigh syndrome (LS) and cytochrome c oxidase (COX) deficiency, mutations of the SURF-1 gene were recently identified. The aim of the present study was to review the MR findings in patients with LS to verify if the genetically homogeneous patients with LS and SURF-1 mutations (LS SURF-1 patients) had a homogeneous MR pattern that could be...

The basal ganglia play a central role in regulating the response selection abilities that are critical for mental flexibility. In neocortical areas, higher cardiorespiratory fitness levels are associated with increased gray matter volume, and these volumetric differences mediate enhanced cognitive performance in a variety of tasks. Here we examine whether cardiorespiratory fitness correlates wi...

Neurons producing the melanin-concentrating hormone (MCH) are distributed in the posterior hypothalamus, but project massively throughout the forebrain. Many aspects regarding the anatomical organization of these projections are still obscure. The present study has two goals: first to characterize the topographical organization of neurons projecting into the cholinergic basal forebrain (globus ...

RATIONALE Cystic fibrosis airways are recurrently exposed to noxious stimuli, leading to epithelial injury. Previous reports suggest that cystic fibrosis airway epithelia may respond to injury by increasing proliferation. OBJECTIVES We sought to determine the characteristics of the proliferating cell population in cystic fibrosis airways. METHODS Six cystic fibrosis and six normal lung sect...