Drosophila germ-line stem cells (GSCs) provide an excellent model to study the regulatory mechanisms of stem cells in vivo. Bag of marbles (bam) has been demonstrated to be necessary and sufficient to promote GSC and cystoblast differentiation. Despite extensive investigation of its regulation and genetic functions, the biochemical nature of the Bam protein has been unknown. Here, we report tha...

Epigenetic silencing is critical for maintaining germline stem cells in Drosophila ovaries. However, it remains unclear how the differentiation factor, Bag-of-marbles (Bam), counteracts transcriptional silencing. We found that the trimethylation of lysine 36 on histone H3 (H3K36me3), a modification that is associated with gene activation, is enhanced in Bam-expressing cells. H3K36me3 levels wer...

MOTIVATION Business Architecture Models (BAMs) describe what a business does, who performs the activities, where and when activities are performed, how activities are accomplished and which data are present. The purpose of a BAM is to provide a common resource for understanding business functions and requirements and to guide software development. The cancer Biomedical Informatics Grid (caBIG®)...

Perpendicular barium ferrite ~BaM! films with Pt interlayers were successfully fabricated. The magnetic and structural properties of BaM films were compared with BaM films without Pt interlayers. It was found that perpendicular c-axis orientation was greatly improved for films with Pt interlayers. Perpendicular remanent squareness is increased, and the c-axis dispersion angle Du50 is decreased ...

The Arg-e Bam is a remarkable example of earthen architecture and construction that was heavily damaged in the Bam, Iran earthquake of 26 December 2003. This paper presents the hypothesis that the collapse of the walls was caused largely by a combination of the effects of (1) the additive changes made to the walls, particularly in recent restorations resulting in variations in the density and r...

Background & Aims: Cutaneous leishmaniasis (CL) is a health problem in the world, including Iran. The objective of this study was to assess the epidemiology of CL and determination of the causative parasite species in the city and suburb of Mohammadabad, Jiroft district. Method: This descriptive and cross-sectional study was performed in census manner. Diagnosis was based on direct smear micros...

The type II restriction endonuclease, Bam HI, has been overexpressed in E. coli by cloning the Bam HI gene in frame with an E. coli Ribosome Binding Site (RBS) under the T7 promoter of an E. coli expression vector pRSET A. The expression level of Bam HI endonuclease using this construct was found to be higher than that reported of the overexpressing clone pAEK14. Our overexpressing clone, pAABR...

Bidirectional associative memory (BAM) is a kind of an artificial neural network used to memorize and retrieve heterogeneous pattern pairs. Many efforts have been made to improve BAM from the the viewpoint of computer application, and few theoretical studies have been done. We investigated the theoretical characteristics of BAM using a framework of statistical-mechanical analysis. To investigat...

seismic refraction and downhole survey were employed to study dynamic characteristics of subsurface materials in bam city, southeast of iran. the data acquisition was performed at 160 p and s-wave refraction stations and 15 boreholes in the city. to derive velocity depth sections along these profiles as well as to perform downhole diagrams, seisimager software was used. based on the obtained va...