Clarithromycin (CLA), a broad-spectrum macrolide, is a poorly soluble drug with dissolution rate limited absorption. The aim of this investigation was to prepare CLA nanoparticles from a ternary ground mixture in the presence of sodium lauryl sulfate (SLS) and polyvinyl pyrrolidone (PVP) as co-grinding water-soluble compounds, in order to improve the drug dissolution rate. Different weight rati...

The impact behavior between the charge and lifter has significant effect to address the mill processing, and is affected by various factors including mill speed, mill filling, lifter height and media shape. To investigate the multi-body impact load behavior, a series of experiments and Discrete Element Method (DEM) simulations were performed on a laboratory-scale mill, in order to improve the g...

Abstract The grain size of clastic rocks is one the most important structural characteristics sediments, which can directly reflect hydrodynamic conditions ancient sedimentary period. preparation conventional rock particle samples usually done by hand wet grinding with a hammer experienced experimenter. For fine-grained rocks, method for preparing has disadvantages long time and low efficiency....

Powdered enamel of extracted human teeth has been used in the estimation of the activity of anticaries agents (S. D. GERSHON, 0. W. NEIDITCH, and R. H. C. LEE, Proc. Toilet Goods Ass., 28:14-17, 1957), as well as a number of studies with a direct or indirect relation to this activity. Correlation of results with different samples of enamel has been difficult because of the numerous variables. I...

This paper compares Discrete Element Model predictions for power and variations in impact and abrasion (low angle impact) breakage with power and grinding rate predictions from the more "traditional" JKMRC models. The DEM predictions are based on measured mill load sizings from a large industrial SAG mill at two operating conditions. The load sizings can also be predicted with reasonable accura...