background   objective:   materials and methods   results   conclusion   key words:   . vitrification, viability, in vitro maturation, gvbd, oocyte, mouse : these results suggest that step-wise vitrification of gvbd oocytes as compared to single step vitrification was better in the rate of survival and in vitro maturation of oocytes. : all non-vitrified oocytes were viable after 24 hr; however,...

background: to evaluate the radioprotective potential of punica granatum fruit rind extract (pgre) in mouse testes. materials and methods: adult male mice were divided into four groups. group i was kept without any treatment. group ii was irradiated with 8gy co60 gamma irradiation and group iii was given pgre one hour before irradiation. group iv was fed with pgre at the rate of 10 mg/kg body w...

background: previous investigations have revealed, cimetidine, a histamine h2-receptor antagonist, show radioprotective effects against gamma- and neutron-induced micronuclei in bone marrow erythrocytes. in this study, the anticlastogenic effects of famotidine and ranitidine, which act similar to cimetidine as histamine h2-receptor antagonists, was investigated. materials and methods : balb/c m...

background: the present study has been carried out to investigate the effects of preovulatory stage gamma-irradiation of female mice in the absence or presence of vitamin e on numerical chromosome abnormalities in 8-cell embryos after mating with non-irradiated males. materials and methods: the 8-11 weeks adult female nmri mice were whole body irradiated at preovulatory stage (post pmsg injecti...

maternal smoking has been recognized as a common cause of low birth weight, preterm birth and the decrease of gestational age period. unfortunately, there is an increasing interest within public especially woman in iran in the tobacco products consumption. on the other hand, the deleterious effect of maternal smoking on human fetus in pregnancy period especially in the first trimester encourage...

objective(s): maternal high-fat diet has been shown to have deleterious effects on the offspring bones. however, there is no study to assess the effects of type and amount of maternal dietary oil in an isocaloric diet, with focus on extra virgin olive oil (evoo). the objective of the current study was to test the hypothesis that type of maternal dietary oil has more effects than its amount in a...

Protein tyrosine phosphatases (PTPases) regulate the tyrosine phosphorylation of target proteins in‌volved in several biological activities including cell proliferation and transformation. Protein tyrosine phosphatase E (PTPE) contains duplicated PTPase-like domains and a short extracellular region. Us‌ing the fluorescence in situ hybridization method, the gene encoding PTPE (locus symbol Ptpre...

Background: Gaucher disease is an autosomal recessive inherited lysosomal storage disorder that affects many of the body's organs and tissues by defective function of the catabolic enzyme β-glucocerebrosidase. Gene therapy is one of the efficient ways for treatment of this disease. Due to the lack of appropriate animal models, in the field of gene therapy little progress has been done.Mate...

Recent studies have established that sex hormones directly or indirectly affect T and B cells and macrophages by manipulating the production of cytokines. In this study the possibility of the effect of 5a-DHT on macrophage (MΦ) nitric oxide (NO) release via interleukin-l, 6 (lL-1β, IL-6) or tumor necrosis factor-a (TNFα) was investigated. The endogenous cytokines IL-1β, IL-6 and TNF-α were ...