UNLABELLED Mycobacterium tuberculosis persists inside granulomas in the human lung. Analysis of the metabolic composition of granulomas from guinea pigs revealed that one of the organic acids accumulating in the course of infection is acetate (B. S. Somashekar, A. G. Amin, C. D. Rithner, J. Troudt, R. Basaraba, A. Izzo, D. C. Crick, and D. Chatterjee, J Proteome Res 10:4186-4195, 2011, doi:http...

Volatile aroma-active esters are responsible for the fruity character of fermented alcoholic beverages such as beer and wine. Esters are produced by fermenting yeast cells in an enzyme-catalyzed intracellular reaction. In order to investigate and compare the roles of the known Saccharomyces cerevisiae alcohol acetyltransferases, Atf1p, Atf2p and Lg-Atf1p, in volatile ester production, the respe...

objective(s) in the present study, the differences in the relaxant effects of aqueous, ethyl acetate and n-butanol fractions of rosa damascena on tracheal smooth muscle of guinea pigs were examined. materials and methods the relaxant effects of three cumulative concentrations of each fraction (0.1, 0.2 and 0.4 g%) in comparison with saline and three cumulative concentrations of theophylline (0....

statement of problem: glucocorticoid-induced osteoporosis is characterized by a decrease in osteoblast numbers and a marked impairment of new bone formation. purpose: the ain of present study was to evaluate the effect of methylprednisolone acetate on bone metabolism and bone mineral density in rats. materials and methods: eighteen male sprague dawley rats (8 weeks old, weighting 180 gm) were r...

lead is known to be a potent neurotoxin that can cause seizure activity in humans and animals. also, epileptic type convulsion is a known complication of hypothyroidism. this study was performed to determine the effect of propylthiouracil (ptu)-induced hypothyroidism and chronic lead exposure on pentylenetetrazol (ptz)-induced kindling parameters. the test was carried out by using male albino r...

chamaemelum nobile (asteraceae) commonly known as 'roman chamomile' is a medicinal plant used for numerous diseases in traditional medicine, although its anticancer activity is unknown. the present study was carried out to investigate the anticancer as well as apoptotic activity of ethyl acetate fraction of c. nobile on different cancerous cell lines. the cells were treated with varyi...